摘要
目的观察甲状腺功能减退症（甲减）患者激素替代治疗前后血脂和心肌酶谱的变化及意义。方法检测72例甲减患者（观察组）治疗前后和60例健康对照组血清中总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）、天门冬氨酸转氨酶（AST）、乳酸脱氢酶（LDH）、α-羟丁酸脱氢酶（HBDH）和肌酸肌酶同工酶（CKMB）水平。结果观察组治疗前TC、TG和LDL-C水平均明显高于对照组（均P〈0．05），而治疗后水平明显下降（均P〈0．05），略高于对照组，但差异无统计学意义（均P〉0．05）。观察组治疗前AST、LDH、HBDH和CKMB水平明显高于对照组（均P〈0．05），而治疗后AST、LDH、HBDH和CKMB水平明显下降（均P〈0．05），治疗后AST、LDH、HBDH和CKMB水平与对照组比较，差异无统计学意义（均P〉0．05）。结论甲减患者经激素替代治疗后血脂和心肌酶谱基本恢复正常，对于防治心血管疾病具有重要意义。
Objective To observe the changes and significance of blood fat and myocardial enzymes in patients with hypothyroid myopathy before and after substitutional treatment. Methods The levels of TC, TG, LDL-C, AST, LDH, HBDH and CKMB were detected in 72 cases with hypothyroid myopathy patients before and after substitutional treatment and 60 healthy controls. Results The levels of TC, TG and LDL-C in hypothyroid myopathy patients before substitutional treatment were significantly higher than those in control group （ all P 〈 0. 05 ）, and then signitlcandy low after treatment,which had no significant difference with control group（ all P 〉 0. 05 ）. The levels of AST, LDH,HBDH and CKMB in hypothyroid myopathy patients before substitutional treatment were significantly higher than.those in control group（ all P 〈0. 05） ,and then significantly low after treatment, which had no significant difference with control group（ all P 〉0. 05）. Conclusion The levels of blood fat and myocardial enzymes were significantly increased in hypothyroid myopathypatients,and recovery to normal after substitutional treatment.
出处
《中国基层医药》
CAS
2011年第17期2327-2328,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
甲状腺功能减退症
替代治疗
血脂
心肌酶谱
Hypothyroid myopathy
Substitutional treatment
Blood fat
Myocardial enzymes
