摘要
本文以大鼠模拟经前期综合征(PMS)肝失疏泄所导致的始发证候肝气逆证为切入点,运用现代分子生物学技术,对肝失疏泄产生肝气逆证时的主要改变指标五羟色胺(5-HT1A)受体基因表达在中枢不同脑区(下丘脑、边缘叶)mRNA水平上的变化进行了探讨。结果显示,在肝失疏泄产生肝气逆证时中枢神经系统中5-HT1A受体的基因表达在mRNA水平均受到一定的抑制,即在肝失疏泄产生肝气逆证时5-HT1A受体的活性明显下降,且下丘脑中5-HT1A受体的活性要比边缘叶中5—HT1A受体的活性下降得显著。
This thesis is about a research on receptor gene expression change at mRNA level in CNS different regions of 5-HT1A on point of original syndrome--liver-qi in syndrome which is caused by the disorder of liver controlling dredging, by using modern molecular biology technology. The result shows that gene expression in mRNA level in CNS of 5-HT1A is always restrained when disorder of liver controlling dredging leads to liver-qi in syndrome, and it is more obvious in hypothalamus than in limbic lobe.
出处
《世界科学技术-中医药现代化》
2005年第5期15-17,共3页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家科学自然基金项目(90209003):PMS肝气逆证基因表达及其非线性动力学特征
