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G蛋白与氟化物 被引量：1

Correlation of G protein and fluoride
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摘要 G蛋白是一个调节GTP水解酶的超家族,在细胞增殖和分化信号转导过程中发挥关键性作用。半个世纪前人们已发现氟化物可以抑制各种酶,氟化物是公认的G蛋白激活剂。尽管目前对于氟化物作用于G蛋白的机制还不完全清楚,但国内外研究均显示氟中毒与G蛋白有关。通过本文可以了解到氟化物作为一个骨形成因子是如何作用于G蛋白而影响成骨细胞增殖,对进一步研究氟中毒致病机理具有一定的参考价值。 G protein is a superfamily of regulatory GTP hydrolases. They play pivotal roles in the signal transduction of cell growth and differentiation. Fluoride had been found to inhibit a variety of enzymes for more than half a century. Fluoride is a well-known G protein activator. The actual mechanism of fluoride action on guanine nucleotide-binding component of AC remained elusive. Many studies seem to suggest a correlation between fluorosis and G protein. The aim of this review is to discuss the basic chemical, biochemical, and toxicological properties of metallic fluoride, to understand the role of Al-F and Be-F complexes in human physiology and its potential effects on our health.
作者 邵红 刘开泰 刘继文
机构地区 新疆医科大学公共卫生学院 中国疾病预防控制中心改水中心
出处 《国外医学（医学地理分册）》 CAS 2005年第3期97-100,105,共5页 Foreign Medical Sciences：Section of Medgeography
基金 国家自然科学基金研究项目-氟对骨骼损伤机制的分子生物学研究
关键词 G蛋白 氟化物 成骨细胞 G protein fluoride osteoblast
分类号 Q51 [生物学—生物化学] Q581 [生物学—生物化学]
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参考文献32

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二级参考文献12

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共引文献14

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国外医学（医学地理分册）
2005年 第3期

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