摘要
目的探讨新生儿败血症的病原菌及其药物敏感情况,指导抗菌药物的应用。方法对我院86例新生儿败血症患儿进行回顾性分析,用K-B法进行药敏实验,并按NCCLS标准判断细菌耐药性。结果凝固酶阴性葡萄球菌(CNS)为主要病原菌,其中表皮葡萄球菌占48.8%,其次溶血性葡萄球菌占10.5%,金黄色葡萄球菌占9.3%,大肠埃希菌占8.1%;细菌对青霉素、氨苄西林、苯唑西林、红霉素耐药性高,万古霉素、亚胺培南、环丙沙星、阿米卡星是目前最敏感抗菌药物。结论重视新生儿败血症病原菌耐药性检测,根据血培养药敏结果选用敏感抗菌药物,可减少细菌耐药性的产生,提高临床治疗效果。
OBJECTIVE To study the pathogens and drug sensitivity test of neonatal septicemia to direct the uses of antibiotics. METHODS The clinical data of 86 cases of neonatal septicemia were analyzed retrospectively. All of the isolates were tested by Kirby-Bauer susceptibility, and the antibiotic resistance Was judged according to NCCLS standard. RESULTS Coagulase-negative Staphylococcus were the main pathogens, among which 48.8% were S. epidermidis, 10.5% were S. haemolyticus, and 9.3% were S. aureus, the other 8.1% were Escherichia coli. Bacteria were highly resistant to penicillin, ampicillin, oxaeillin and erythromycin. Vancomycin, imipenem, ciprofloxacin and amikacin were the most sensitive drugs presently. CONCLUSIONS Much attention should be paid to drug resistance detection in the treatment of neonatal septicemia. Choosing sensitive antibiotics based on the drug sensitivity tests may decrease the occurrence of drug-resistant bacteria and increase the clinical curative effects.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2005年第9期1071-1073,共3页
Chinese Journal of Nosocomiology
