摘要
采用放免法检测165例Graves病（GD）患者，105例桥本氏甲状腺炎（HT）患者及107例正常人血清抗三碘甲状腺原氨酸抗体（T3Ab）。结果显示，GD未治组、缓解组和HT组T3Ab的阳性率分别为0.036、0．069和0．019，其中GD缓解组中2例T3Ab阳性者，其临床表现与血清T3和／或FT3不相符合。正常人T3Ab皆为阴性。所有T3Ab阳性的病人血中均可检出甲状腺球蛋白抗体（TGAb）。提示部分甲状腺疾病患者血中存在抗甲状腺激素抗体，此抗体可干扰血清甲状腺激素的放免测定结果。
The autoantibodies to triiodothyronine (T3Ab) were measured by sensitive radioimmunoassay. T3Ab were de tected in 4 out of 58 patients with remitted Graves' disease(GD), among the 4, 2 patients were clinically discordant with their serum levels of total/or free T3. T3Ab were alao demonstrated in 5 out of 137 patients with untreated GD, and in 2 out of 105 patients with Hashimoto's thyroiditis. However, the same antibodies were not found in 107 healthy control subjects. All the patients with positive T3Ab had antithyroglobulin antibodies (TGAb). The results suggest that T3Ab could be a subpopulation of heterogenous TGAb. And the presence of T3Ab should be suspicious whenever the results of thyroid function tests are discordant with patients' clinical state.
出处
《江苏医药》
CAS
CSCD
1995年第3期146-148,共3页
Jiangsu Medical Journal
