摘要
目的探讨创伤性休克时心脏、肺脏血栓调节蛋白表达的变化和意义。方法复制大鼠创伤性休克模型,采用免疫组织化学技术测定休克后30min、120min时心脏、肺脏血栓调节蛋白的表达水平。结果正常对照组大鼠心脏血栓调节蛋白表达以阴性和弱阳性为主,休克后30、120min时心脏血栓调节蛋白阳性表达水平较对照组升高,有统计学意义,尤其以休克后120min表达显著升高。正常对照组大鼠肺脏血栓调节蛋白表达以弱阳性及阳性为主,创伤休克30min时与对照组相比差异无显著性,创伤休克120min时与对照组及创伤休克30min组相比统计学分析差异显著。结论创伤性休克可致大鼠重要脏器心脏、肺脏血栓调节蛋白表达,表达水平与创伤休克程度相关,这与创伤休克时存在明显的微循环系统紊乱和内皮功能障碍有关。
Aim To investigate the expression and significance of thrombomodulin in hearts and lungs during traumatic shock of rats. Methods Rats were subjected to traumatic shock and thrombomodulin in hearts and lungs were measured by immunohistochemical assay after the shock. Results 30,120 mins after shock, expression of thrombomodulin in hearts gradually increased, especially that of 120 min after shock. There was no relationship between the control group and the group of 30 min after shock. The group of 120 min after shock was apparently diverse in relation to the other two groups. Conclusion Thrombomodulin is up-regulated in hearts, lungs of rats during traumatic shock. With traumatic degree aggravating, expression of thrombomodulin increased,which is associated with microcirculatory perturbation and endothelial dysfunction .
出处
《安徽医药》
CAS
2005年第8期606-608,共3页
Anhui Medical and Pharmaceutical Journal
