摘要
【目的】观察冠心病患者在体外反搏(ECP)治疗前后循环血液中肾素血管紧张素系统与指脉的变化,分析它们之间的关系,探讨ECP防治冠心病的机制。【方法】对20例1个月内发生心肌梗死或心绞痛的患者进行了ECP治疗,同时监测指脉波参数。分别于第1次反搏前、3个疗程结束时采血,用放免及紫外分光光度法检测血液中肾素活性、血管紧张素Ⅱ(angiotensinⅡ,ANGⅡ)质量浓度及血管紧张素转换酶(angiotensin-convertingenzyme,ACE)活性。【结果】指脉波呈上升趋势,但组间无统计学意义。1个疗程后,肾素活性与ANGⅡ浓度高于反搏前;2个疗程后,ANGⅡ降至反搏前水平,ACE低于反搏前;3个疗程后,肾素活性降至反搏前水平,ANGⅡ与ACE低于反搏前。血浆ANGⅡ水平与指脉波成负相关关系。【结论】体外反搏对血流动力学的改善作用可能是其抑制肾素血管紧张素系统的机制之一。
[Objective] To investigate the relationship between circulating renin-angiotensin system (RAS) and finger plethysmography in patients with coronary heart disease (CHD) treated with external counterpulsation (ECP). [Methods] Twenty patients with CHD were treated with three courses of ECP. During the treatment, finger plethysmography were recorded. The circulating RAS, including plasma rennin activity (PRA), angiotensinⅡ(ANGⅡ) level and serum angiotensin-converting enzyme (ACE) activity, were determined before ECP and at the end of three courses of ECP. [Results] Finger plethysmography had a tendency of increasing. But there was no significant difference among groups. After a course of ECP, PRA and ANGⅡ level increased. At the end of the second course, ANGⅡreduced to the level before ECP, then became lower than that before ECP. ACE was lower than that before ECP. After three courses of ECP, PRA reached to the level before ECP and ANGⅡ and ACE was lower than that before ECP. There was negative correlation between finger plethysmography and ANGⅡ level. [Conclusion] Improvement of haemodynamics may be one mechanism of inhibited RAS activity by ECP treatment.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2005年第4期446-448,共3页
Journal of Sun Yat-Sen University:Medical Sciences
基金
中美辅助循环基金资助项目(1998)
