摘要
肾集合管癌少见，其生物学行为尚不十分清楚。我们在近４年间收治５例，男３例，女２例，年龄４１～６７岁。主要临床表现为血尿、消瘦、低热。４例行根治性肾切除术，３例分别经３个月，２、２．５年随访无复发，ｌ例术后１年２个月死于肺转移。１例因肾门、腔静脉旁淋巴结广泛受累仅作姑息性肾切除，术后２个月出现骨转移。病理所见：肿瘤灰白，位于髓质，镜检呈腺管乳头状结构，间质丰富，邻近集合管异型增生。免疫组化检查高分子细胞角蛋白，花生凝集素及上皮细胞膜抗原均阳性。结合文献对集合管癌的若干诊断和治疗问题进行讨论。
Collecting duct carcinoma of the kidney is rare and its biological behavior is not well known. 5 cases of collecting duct carcinoma(3 males and 2 females,age 41～67 years)were identified in the last 4 years.The clinical,pathologic and immunohistochemical characteristics of these tumors were presented.The most common symptoms were hematuria, fatigue,marasmus and low fever.4 patients underwent radical nephrectomy,of those 3 have been alive without evidence of recurrence for 3 months,2 and 2.5 years,respectively,whereas 1 died of lung metastasis 14 months after operation.One patient was submitted to simple nephrectomy because of extensive regional nodal invasion and bone metastasis was noted 2 months afterwards.Grossly the tumor had a whitish appearance with the bulk of the mass located in the renal medulla.Histologic examination showed prominent tubulo-papillary structures.Marked desmoplastic reaction was noted and atypical hyperplastic changes were found in the adjacent collecting ducts.Immunohistochemical studies revealed positivity with antibodies to epithelial membrane antigen,high molecular weight cytokeratins and peanut agglutinin,With a review of the literature some issues concerning the diagnosis and management of these tumors were discussed.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1994年第5期337-339,共3页
Chinese Journal of Urology
关键词
肾肿瘤
癌
集合管
病例报告
Kidney neoplasms Cancer Collecting duct
