摘要
[目的 ]通过测定血清中T -PSA与F -PSA的比值 ,探讨F -PSA/T -PSA在前列腺癌(PCa)与前列腺增生 (BPH)鉴别诊断中的价值。 [方法 ]采用罗氏电化学发光仪RocheElecsys10 10测定BPH和PCa患者血清中的T -PSA、F -PSA ,并计算F -PSA/T -PSA值。 [结果 ]T -PSA在 4 .0～ 5 0 .0 μg/L时 ,BPH和PCa患者有重叠区 ,而且在此区域内 ,两组患者的T -PSA差异无显著意义 (P >0 .0 5 ) ,而F -PSA/T -PSA值的差异有显著意义 (P <0 .0 5 )。 [结论 ]F -PSA/T -PSA值作为T -PSA的辅助指标 ,对T -PSA在 4 .0～ 5 0 .0 μg/L范围的PCa和BPH患者具有较大的鉴别诊断意义。
Objective To explore the significance of F-PSA/T-PSA ratio in differential diagnosis between benign prostate hyperplasia (BPH) and prostate cancer (PCa) , through the detection of the level of serum total prostate specific antigen (T-PSA) and free PSA (F-PSA). [Methods] Two groups males with BPH and PCa were included in this study , F-PSA and T-PSA were measured with the Roche Elecsys 1010. The F-PSA/T-PSA was calculated based on the results.[Results] When T-PSA was between 4.0 and 50.0 μg/L, there was the range of overlapping of T-PSA in BPH and PCa patients, T-PSA couldn't be a differential maker for the two conditions (P>0.05) where as F-PSA/T-PSA ratio could (P<0.05).[Conclusion] F-PSA/T-PSA ratio being an adjuvant marker of T-PSA of importance on the differential diagnosis in patients when T-PSA is between 4.0～50.0 μg/L.
出处
《大连医科大学学报》
CAS
2005年第1期54-56,共3页
Journal of Dalian Medical University
关键词
前列腺特异性抗原
前列腺癌
前列腺增生
prostate specific antigen (PSA)
prostate cancer (PCa)
benign prostate hyperplasia(BPH)
