摘要
目的 探讨稀土元素铈 (Ce)对SD雌性、雄性大鼠的某些生物学效应。方法 采用动物解剖与生化检测相结合的方法 ,研究长期饮用不同剂量三硝酸铈溶液对大鼠各脏器系数及肝、肾超氧化物歧化酶(SOD)活力和丙二醛 (MDA)含量的影响。结果 与对照组相比 ,低、中、高剂量组雄性大鼠肺器系数均明显升高 ,分别为 (4 1± 0 8) ,(3 7± 0 4 ) ,(4 3± 1 5 )mg/ g ;低、中剂量组雌性大鼠肺器系数明显增加(P <0 0 5 ) ;低剂量组雌性大鼠肝脏重量明显增加 (33 2± 6 3)mg/ g ,而且铈对雌、雄两性大鼠作用的靶器官以及作用程度有所差异 ;各剂量组大鼠肝脏SOD活力均明显降低 ,分别为 (30 34 6± 5 6 6 6 ) ,(30 5 0 5± 4 5 6 3) ,(30 83 4± 5 6 0 3)U/ml,中、高剂量组大鼠肾脏SOD活力也明显下降 (P <0 0 5 ) ;但肝、肾MDA含量无明显变化。结论 稀土元素铈对大鼠具有较强的毒害作用 ,主要靶器官为肝脏和肺 ,并使肝。
Objective To study some biological effects and mechanisms of cerium on male and female Spraque-Dawley(SD)rats.Methods The rats were fed with cerium-containing solution for a long term,instead distilled water was fed for controls for 5 months.Then the rats were sacrificed to get the ratio of organs to body weight by weighing;the activities of SOD and the contents of MDA in the liver and kidney were detected.Results Compared with the control group,the ratios of lungs to body weight of male rats in three dosages groups increased obviously,(4.1±0.8),(3.7±0.4),and(4.3±1.5)mg/g respectively;while in female rats obvious increase was found only in low and middle dasages groups(P<0.05).The ratio of liver to body weight of low dose female rats increased remarkably(33.2±6.3)mg/g.Different effects of cerium on target organs of male and female rats were observed.Cerium could significantly reduce the activities of SOD(P<0.05)in liver of three dosages groups,( 3 034.6±566.6),( 3 050.5±456.3),and( 3 083.4±560.3)U/ml respectively.The activities of SOD in kidney of middle and high dosages groups were down obviously(P<0.05),while the levels of MDA in liver and kidney had no obvious change.Conclusions Cerium has toxic effects on liver and lung of rats,and could decrease the antioxidation ability of the liver and kidney.
出处
《工业卫生与职业病》
CAS
CSCD
北大核心
2005年第2期76-79,共4页
Industrial Health and Occupational Diseases
基金
浙江省教育厅资助项目 ( 2 0 0 2 0 85 3 )
浙江省大型仪器分析测试基金资助项目 ( 0 2 0 82 )
关键词
铈
靶器官
超氧化物歧化酶
丙二醛
Cerium
Target organs
Superoxide dismutase
Malondialdehyde
