摘要
永久性肝动脉结扎（ＰＨＡＬ）后侧枝循环的建立．是ＰＨＡＬ治疗肝癌效果不持久的原因之一．如何防止或减少侧枝循环的形成．是肝癌缺血治疗的重要环节之一。通过大鼠选择性腹腔动脉造影（ＳＣＡ）的方法．观察ＰＨＡＬ和肝动脉反复暂时阻断（ＲＴＢＨＡ）后侧枝形成的情况。ＰＨＡＬ后２ｗｋＳＣＡ即可见侧枝循环．随着时间延长．侧枝愈加明显丰富，其主要来源是肠系膜上动脉、腹腔动脉和大网膜。ＲＴＢＨＡ后２ｗｋ，ＳＣＡ未显示侧枝形成。实验结果表明肝动脉的间歇阻断可以防止侧枝循环的建立。这为ＲＴＢＨＡ的临床运用提供了实验依据。
One of the causes of short-last-iug effect on liver cancer with Permanent hepaticartery ligation(PHAL)is the development of arterial collaterals.How to reduce or prevent theformation of collaterals after PHAL is a key factor for ischemic therapy of liver cancer.To observe the formation of arterial collaterals afterPHAL and repeated temporary blockade of thehepatic artery(RTBHA ),selective celiac angiography(SCA)was performed in rats.For only two weeks after PHAL,arterial collateralscould be shown on SCA,which became more obvious as time goes on and came mainly from superior mesenterical artery,celiac art.ery andgreater omentum. There were no demonstrablecollaterals in RTBHA group two weeks later.Itis suggested that RTBHA would prevent the development of arterial collaterals,which providesthe experimental basis for the clinical practice ofRTBHA.
出处
《肝胆外科杂志》
1994年第4期211-213,共3页
Journal of Hepatobiliary Surgery
