摘要
给大鼠戊四唑(PTZ)亚惊厥剂量(30 mg/kg,ip),每日一次,连续给药28 d.建立了戊四唑化学点燃模型。采用七点评分法观察行为惊厥和脑电图变化。凡连续5次获二级或二级以上惊厥者,被认为完全点燃。结果表明,28 d龄大鼠总点燃率为74%,全身性肌阵挛为其典型症状。行为惊厥与脑异常放电同步。凡有行为惊厥者皆伴有恼电图棘波或棘慢波放电。停止处理4周后。点燃大鼠仍保持其点燃状态。提示本文所用PTZ剂量合理,方法可靠且简单易行。
An ideal animal model of chemical kindling mimicking human epilepsy was developed in 28 day-old rats. Rats were given pentylenetetrazol (PTZ) 30 mg/kg, ip, once per day for 28 consecutive days; after stopping treatment for one week, the rats were retreated using the same dose of PTZ until reaching the kindled criterion. The kindled rate was 74%. The behavioral seizure and EEG discharges were synchronized. All kindled rats still kept their high seizure state after the experiments.
出处
《药学学报》
CAS
CSCD
北大核心
1993年第7期486-489,共4页
Acta Pharmaceutica Sinica
关键词
戊四唑
点燃
癫痫
Pentylenetetrazol
Kindling
Seizure model
