摘要
目的 探讨影响帕金森病(PD)患者生活质量(QoL)的主要因素。方法 采用PD统一评分量 表第2部分(UPDRS Ⅱ)对97例PD患者的健康相关生活质量(HRQoL)进行评估,同时选用汉密尔顿焦虑量 表(HAMA)、汉密尔顿抑郁量表(HAMD)、简易精神状态量表(MMSE)、PD统一评分量表第1及第3部分 (UPDRS Ⅰ,UPDRS Ⅲ)、Hoehn Yahr分级作为评估患者的焦虑状况、抑郁状况、认知功能、运动障碍程度的主 要指标。结合患者的年龄、起病年龄、性别、病程、左旋多巴累积用量、有无症状波动、有无精神症状等可能影 响QoL的因素评价上述指标对PD患者QoL影响的程度。结果 逐步线性多重回归分析显示:对PD患者 HRQoL(UPDRS Ⅱ分数)影响最大的因素是运动症状(UPDRS Ⅲ)、病程、抑郁程度(HAMD抑郁评分)及有无 精神症状(UPDRS Ⅰ)。上述4项因素相加对UPDRS Ⅱ分数的影响起决定作用的占78.4%。结论 在本次 调查的样本中,心理与躯体因素联合作用影响PD患者的QoL。因此,在诊治过程中应联合治疗心理及躯体疾 患,加强康复锻炼,完善生活辅助用具,以提高PD患者的QoL。
Objective To identify the essential factors involved in the health related quality of life(HRQoL) in patients with parkinson’s disease(PD).Methods The HRQoL in 97 patients with PD was estimated using unified parkinson's disease rating score II(UPDRS-II). Meanwhile, anxiety, depression, cognition and motor symptoms were evaluated by some methods, i.e. Hamilton anxiety scale(HAMA), Hamilton depression scale(HAMD), mini-mental state examination(MMSE), UPDRS-I,UPDRS-III, Hoehn-Yahr scale. The factors, affected the quality of life in the patients, such as age, onset, gender, course, cumulative levodopa dose, symptom fluctuation as well as psychiatric symptom were also investigated.Results Multiple stepwise regression analysis showed that the main factors involved in the HRQoL in patients with PD were motor symptom(UPDRS-III), course of disease, depression(HAMD) and presence of psychiatric symptoms(UPDRS-I). These factors accounted for 78.4% of the variance of HRQoL scores.Conclusions The factors interfered with the HRQoL of parkinsonian patients are mental factors(HAMD) and physical factors(UPDRS-III). Therefore, it is very important to improve depression as well as alleviate motor symptoms during the treatment of PD. Rehabilitation and assistant appliance are also of value.
出处
《临床神经病学杂志》
CAS
北大核心
2005年第1期16-18,共3页
Journal of Clinical Neurology
关键词
帕金森病
生活质量
抑郁
焦虑
痴呆
parkinson’s disease
quality of life
depression
anxiety
dementia
