摘要
目的监测和了解头孢吡肟对临床常见革兰阴性菌体外抗菌活性。方法从1999～2002年收集的临床常见革兰阴性杆菌50528株(主要为尿液、痰、伤口及其分泌物标本),连续监测4年。药物敏感性试验采用纸片扩散法,WHONET5软件进行结果分析。结果1999～2002年头孢吡肟对肠杆菌科细菌的敏感性为700%～952%;对铜绿假单胞菌敏感性为739%～775%。1999～2002年肠杆菌科细菌临床分离株对头孢噻肟、头孢他啶和头孢吡肟耐药性变迁的比较表明,头孢吡肟耐药率增加幅度低于头孢噻肟、头孢他啶;铜绿假单胞菌对头孢吡肟耐药率增加幅度明显低于哌拉西林、阿米卡星和头孢他啶。结论头孢吡肟对大肠埃希菌、肺炎克雷伯菌、弗劳地枸橼酸杆菌、产气肠杆菌、阴沟肠杆菌、奇异变形杆菌、铜绿假单胞菌和鲍曼不动杆菌有较好的体外抗菌活性。
Objective To study on the antimicrobial activities of cefepime against clinical isolates of Gram negative bacilli in vitro around the national networks of antimicrobial resistance from 1999 to 2002 Methods Disc diffusion test was used to study the antimicrobial resistance WHONET 5 was applied for analysis Results In the period of study from 1999 to 2002, 50 528 Gram negative bacteria strains were collected with first isolate by patient Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae were the most common strains among the isolates Major specimens were sputum, urine as well as wounds and secretions Most of Enterobacteriaceae isolates were susceptible to cefepime (70 0%～95 2%) Susceptible rates of Pseudomonas aeruginosa to cefepime were 73 9% to 77 5% Change of antimicrobial resistance was not found in Enterobacteriaceae isolates resistant to cefepime by comparing with cefotaxime and ceftazidime Increasing rate of Pseudomonas aeruginosa in resistance to cefepime was lower than that to piperacillin, amikacin and ceftazidime in the study period Conclusions Cefepime was good antimicrobial activities against the clinical isolates of E coli, K pneumoniae, C freundi,E areogenes, E cloacae, P mirabilis, P aeruginosa and A baumannii in vitro
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2004年第11期747-751,共5页
Chinese Journal of Laboratory Medicine
关键词
头孢吡肟
抗生素
革兰阴性杆菌
体外敏感性
耐药性监测
Cefepime
Microbial sensitivity tests
Gram-negative bacteria
Drug resistance, microbial
