摘要
目的 探讨肌钙蛋白T(cTnT)与降钙素基因相关肽 (CGRP)对急性冠状动脉综合征 (ACS)患者危险分层及预后评估的价值。方法 选择ACS患者 15 8例 ,其中ST段抬高心肌梗死 (STEMI) 72例 ,非ST段抬高心肌梗死(NSTEMI) 2 3例 ,不稳定型心绞痛 (UA) 6 3例 ,入院后立即抽取肘静脉血采用ELISA法测定cTnT和CGRP水平 ,并观察患者住院期间和随访 6个月期间主要心血管事件 (MACE)。结果 NSTEMI组与STEMI组相比 ,cTnT及CGRP水平无显著性差异 ,但NSTEMI组CGRP水平高于STEMI组 ,cTnT水平低于STEMI组。与STEMI组相比 ,UA组患者cTnT水平明显降低 (P <0 .0 5 ) ,而CGRP水平显著增高 (P <0 .0 5 )。陈旧心肌梗死、左心室射血分数、cTnT及CGRP水平是ACS患者MACE发生的独立预测因子。结论 cTnT及CGRP水平在NSTEMI组与STEMI组相似 ,在心绞痛组cTnT亦有轻度增高 ;心肌梗死较心绞痛患者发病时CGRP水平低 ;cTnT及CGRP水平是ACS患者MACE发生的独立预测因子。
Objective To investigate the value of cardiac troponin T(cTnT) and calcitonin gene-related peptide (CGRP) on risk stratification and prognosis in patients with acute coronary syndromes (ACS). Methods Among 158 consecutive patients, ST-elevation myocardial infarction (STEMI)72 patients, non-ST elevation myocardial infarction (NSTEMI) 23 patients, unstable angina (UA) 63 patients. The samples were drawn simultaneously, early release kinetics of cTnT and CGRP were analyzed with ELISA. Composite end point of major cardiovascular events (MACE) in hospital and at 6 months. Results There were no difference at cTnT and CGRP level in NSTEMI and STEMI groups; but cTnT was significantly lower in UA group than STEMI group (P<0.05), CGRP was significantly higher in UA group than STEMI group (P<0.05). In our study, previous myocardial infarction,ejection fraction,cTnT and CGRP were independent protective factors of MACE in patients with ACS. Conclusion There were no difference at cTnT and CGRP level in NSTEMI and STEMI groups and minor elevation of cTnT in UA group; CGRP level was lower in UA group than myocardial infarction group; cTnT and CGRP were independent protective factors of MACE in patient with ACS.
出处
《中国心血管杂志》
2005年第1期14-16,共3页
Chinese Journal of Cardiovascular Medicine
