摘要
对心肌肌酸激酶同工酶MB(CK MB)、肌红蛋白、心肌肌钙蛋白T(cTnT)和心肌肌钙蛋白I(cTnT)用于诊断心肌梗死(MI)和对急性冠状动脉综合征分级的系统评价结果表明,在症状发生后的12～48小时采样分析,CK MB质量诊断MI的临床灵敏度和特异性分别是98.8%和89.6%。肌红蛋白有高的阴性预示值,在症状发生后的2～6小时采样分析,有高的临床灵敏度。在症状发生后的12小时采样分析cTnI,诊断MI可达到最佳临床灵敏度,临床灵敏度和特异性分别是90%和97%。在症状发生后的12小时采样分析cTnT,诊断MI的临床灵敏度和特异性分别是98.2%和8.8%,临床特异性降低与检测到微小心肌受损有关。cTnT和cTnI比CK MB预测急性冠状动脉综合征危险性更有用。
There is systematic review evidence for use CK-MB,myoglobin,cardiac troponin T(cTnT) and cardiac troponin I(cTnI) for diagnosis of mycardial infarction(MI)and riskstratification of the acute coronary syndromes.CK-MB mass for diagnosis of MI yieldded a clinical sensitivity and specificity are 98.8% and 89.6% respectively for sampling at 12～48 hours.Myoglobin has high negative predictive value and high sensitivity 2～6hours after presentation.Clinical sensitivity and specifictiy of cTnI are 90%and 97% respectively for sampling over 12hours after symptoms onset.cTnT had a sensitivity of 98.2% for diagnosis of MI with lower specificity due to detection of minor myocardial injury.Both cTnT and cTnI are more useful for stratifying risk in acute coronary syndrome patients than CK-MB.
出处
《广州医药》
2005年第2期3-5,共3页
Guangzhou Medical Journal
