摘要
目的:探讨免疫功能正常状态原发性脑淋巴瘤的MRI特征及其MRI表现的病理基础。材料与方法:回顾性分析13例未经治疗的免疫功能正常状态原发性脑淋巴瘤患者的临床、病理及MRI表现。MR扫描序列包括SET1WI、FSET2WI、EPIDWI及增强SET1WI。结果:13例患者共计19个病灶,其中5例(38%)有多发病灶。T1WI病灶为等、低信号,其中3个病灶伴有局灶性高信号;12个病灶在T2WI上为等、低信号;14个病灶在DWI上为等、高信号,病灶增强部分的ADC值为0.59×10-3～0.91×10-3mm2?s,均值及标准差为(0.71±0.20)×10-3mm2?s,对侧正常脑组织白质的ADC值为(0.85±0.08)×10-3mm2?s。所有病灶均有强化,12个病灶为均匀强化。大多数病灶病理上表现为瘤细胞密集、高核浆比,瘤细胞沿血管周围排列呈“袖套”样改变,血管增生不明显,病灶内出血坏死少见。结论:免疫功能正常状态原发性脑淋巴瘤的MRI表现与其病理亚型无关,但与其细胞密集、高核浆比及有无出血坏死密切相关。
Objective To describe the MRI features of primary cerebral lymphoma in immunocompetent patients and correlate with histopathologic findings. Methods The MRI images pathologic specimens and clinical records of 13 pretreatment immunocompetent patients with primary cerebral lymphoma were reviewed. The imaging and pathologic characteristics were tabulated. MR spin echo T1 weighted,fast spin echo T2 weighted and echo planar diffusion weighted images were obtained. Results A total of 19 lesions were present in 13 patients 5 patients38% had multiple lesions. Nearly all lesions were isointense or hypointense on T1WI except 3 lesions with focal hyperintensity 12 lesions were isointense or hypointense on T2WI and 14 lesions were isointense or hyperintense on diffusion weighted images. The ADCs of the enhance parts in the lesions were in the range of 0.59×10-3 to 0.91×10-3mm2s mean(0.71±0.20)×10-3mm2s and The ADCs of normal white matter in the contralateral hemisphere were(0.85±0.08)×10-3mm2s. Contrast enhancement was performed in all lesions and 12 lesions showed a homogeneous enhancement pattern. In pathologic specimen nearly all lesions showed dense cellularity of the tumor low vascularity and its predilection for the periventricular region. Haemorrhage or necrosis were rare. Conclusion Primary cerebral lymphoma has MRI characteristics that correlate with the high nuclear to cytoplasmic ratio dense cellularity and the absence of hemorrhage or necrosis of tumor but does not correlate with the histologic subtype of tumors.
出处
《中国临床医学影像杂志》
CAS
北大核心
2005年第1期5-7,33,共4页
Journal of China Clinic Medical Imaging
关键词
脑肿瘤
淋巴瘤
磁共振成像
brain neoplasms lymphoma magnetic resonance imaging
