摘要
目的 通过对连续碳纤维增强聚烯烃复合材料的毒理学试验 ,鉴定其作为硬组织修复材料的生物安全性 ,为临床应用提供依据。 方法 采用标准的毒理学试验方法将实验材料分别进行 7个方面检测 :1溶血试验 ;2热源试验 ;3致敏试验 ;4细胞毒性试验 ;5鼠伤寒沙门氏菌回复突变试验 ;6哺乳动物培养细胞染色体畸变试验 ;7骨髓微核试验。 结果 所有实验样品各项检测指标的结果显示其材料无溶血性、无热源性、无致敏性、无细胞毒性 ,以及不导致染色体畸变。 结论 连续碳纤维增强聚烯烃复合材料具有良好的生物安全性 ,满足作为硬组织修复材料生物安全性要求。
Objective To evaluate the biological safety of continuous carbon fiber reinforced polyolefin as hard tissue repair material. Methods Biocompatibility of the material was evaluated through hemolysis test, pyrogen test,skin irritation test, cytotoxicity test, ames test, in vitro chromosome aberration test, and bone marrow cells Micronuclei test. Results No obvious hemolysis, pyrogenic characteristics, sensitivity, cytotoxxicity, and mutagenicity were observed. Conclusion The continuous carbon fiber reinforced polyolefin composite material is of good biological safety. It meets all the demand made by biological safety as hard tissue repair material.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2005年第1期45-47,共3页
Chinese Journal of Reparative and Reconstructive Surgery
