摘要
口服免疫可诱导机体产生有效的免疫应答和免疫耐受。其通过胃肠粘膜进行抗原递呈 ,较经传统注射途径的免疫效果和依从性好 ,且简易便捷 ,是更为理想的免疫途径。口服疫苗有多种载体系统 ,某些经改造的细菌如沙门氏菌、大肠杆菌、特别是乳酸菌属被认为是有前景的口服疫苗载体 ,因口服后可在肠道寄生繁殖 ,故可大大提高免疫的效率。本文围绕口服免疫主要的机制和口服疫苗的研究进展进行综述。
Oral immunity is known to be appropriate for immune activation as well as tolerance induction, in which antigen presenting is completed through a mucosal route. It has been demonstrated to be an optimal way for immunity, better than through a traditional way of injection in immunoregulation efficacy, compliance and administration approach. There are many vector systems of bacteria serving as carriers for oral vaccines, including some attenuated Salmonella, Escherichia coli, particularly lactic acid bacteria, as a safe organism, which has been considered to be a perspective candidate carriers for oral vaccine because of its lower intrinsic immunogenicity.
出处
《医学分子生物学杂志》
CAS
CSCD
2004年第5期316-319,共4页
Journal of Medical Molecular Biology
