摘要
目的探讨奥氮平治疗对精神分裂症患者的疗效及生活质量的影响。方法对符合CCMD 3精神分裂症诊断标准的 83例患者 ,根据随机对照方案分别使用奥氮平和氯氮平治疗 ,疗程 12个月。观察其疗效与副作用 ,并采用WHOQoL BREF量表衡量患者的生活质量 ,分析量表中各领域的计分。结果最后一次评定 ,奥氮平组BPRS总分降至 15 .2 6± 4.2 1,与治疗前比较有显著性差异 (P <0 .0 1) ;氯氮平组BPRS总分降至 16.3 2± 4.49,与治疗前比较有显著性差异 (P <0 .0 1)。两组间疗效无显著性差异 (P >0 .0 5 )。氯氮平组副作用比奥氮平组多。经 12个月治疗 ,奥氮平组的身体健康、心理健康、社会关系、环境因素的分值分别为 69.86± 5 .5 4、91.69± 12 .2 3、92 .98± 12 .2 5、91.86± 11.93 ;氯氮平组的身体健康、心理健康分、社会关系、环境因素的分值分别为 67.0 4± 10 .78、77.86± 11.98、81.43± 12 .18、79.5 6± 11.82。两组患者生活质量较治疗前均有显著改善 (P <0 .0 1) ,在心理健康、社会关系和环境因素等三方面 ,奥氮平优于氯氮平 (P <0 .0 1)。结论奥氮平和氮平对精神分裂症疗效相当 ,但在提高患者的生活质量方面 ,奥氮平优于氯氮平 。
ObjectiveTo investigate the influence on efficacy and quality of life of olanzapine in schizophrenia.Methods83 adult patients were recruited in this study. All the cases were selected in accordance with the CCMD-3 diagnosis standard and randomized into two groups, treated with olanzapine and clozapine for the 12-month therapeutic course. Besides the effects and adverse effects of durgs were observed, WHOQOL-BREF instruments were used to evaluate the patients' quality of life before and after drug administration, by means of analyzing the scores in every domains. ResultsFor the last assessment,The scores of BPRS decrease to 15.26±4.21 in olanzapine group,was significantly lower than the beginning(P<0.01); the scores of BPRS decrease to 16.32±4.49 in clozapine group, was significantly lower than the beginning (P<0.01). Two groups showed similar effects, with no significance.The side effects were more in clozapine group than those in olanzapine group. 12 months after treatment, the scores of physical health, psychological health, social relationship, and environment in olanzapine group were 69.86±5.54,91.69±12.23,92.98±12.25,91.86±11.93;and the scores of physical health, psychological health, social relationship, and environment in clozapine group were 67.04±10.78, 77.86 ±11.98,81.43±12.18,79.56±11.82 , and the scores of four domains in WHOQoL-BREF instruments had been improved significantly in two groups(P<0.01). In the domains of Psychological Health, Social Relationship, and Environment, olanzapine was superior to clozapine(P<0.01). Conclusion Olanzapine is as effective as clozapine for the treatment of schizophrenia ,but it has more advantage than clozapine to improve quality of life in schizophrenia and would be helpful to patients' longterm rehabilitation.
出处
《中国行为医学科学》
CSCD
2004年第4期396-398,共3页
Chinese Journal of Behavioral Medical Science
关键词
奥氮平
氯氮平
精神分裂症
疗效
生活质量
药物治疗
Olanzapine
Clozapine
Schizophrenia
Efficacy
Quality of Life
Comparative study
