摘要
目的：观察DF、NP、TP方案化疗鼻咽癌肺转移的疗效。方法 A组初治（ A1组）予DF（ DDP 20 mg/m2，第1～5天；5-FU 0．5 g/m2，第1～5天）化疗，有效者（ CR/PR）共3～4个周期。复治（ A2组）：化疗2周期未达PR改用NP（ NVB 25 mg/m2，第1、8天；DDP 30 mg/m2，第2～4天）方案化疗2周期；既往曾DF化疗者予NP化疗2周期，化疗2周期未达PR改用TP（ PTX 175 mg/m2，第1天，DDP 30 mg/m2，第2～4天）方案2周期。 B组初治（ B1组）予DF化疗，有效者（ CR/PR）共3～4个周期。复治（ B2组）：化疗2周期未达PR改用TP方案2周期；既往曾DF化疗者TP方案化疗2周期，化疗2周期未达PR改用NP方案化疗2周期。均每21天为1个周期。结果 DF、TP初治者2组有效率相近，白细胞、血红蛋白毒性，无显著差异，P值＞0．05；NP、TP方案对曾DF方案化疗者有效率42．5％、45．0％，NP、TP方案化疗无效者互换方案化疗有效率低于10．0％；TP方案初治中位进展期5．3个月。结论 NP、TP方案二线使用更有优势。
Objective To observe the curative effect of DF /NP /TP regimens for nasopharyngeal carcinoma with lung metastasis.Methods Group A:In the initial treatment group A1,patients were treated with DF regimen(DDP 20 mg/m2 D1-5,5-FU 0.5 g/m2 D1-5),2patients who were effective(CR or PR) were continued with the treatment for 3-4 cycles.In the retreatment group A2:patients who were not effective(SD or PD) after 2 cycles were administered with NP regimen(NVB 25 mg/m2 D1、5, DDP 30 mg/m2 ,D2、3、4) for 2 cycles,patients were administered with NP regimen for 2 cycles of retreatment ( previous chemo-therapy with DF regimen),patients who were not effective (SD or PD) after 2 chemotherapy cycles were administered with TP reg-imen(PTX 175 mg/m2,D1,DDP 30 mg/m2,D2、3、4) for 2 cycles.Group B:In the initial treatment group B1,patients were ad-ministered with TP regimen(PTX 175 mg/m2,D1,DDP 30 mg/m2,D2、3、4).Patients who were effective(CR or PR) were con-tinued with the treatment for 3-4 cycles.In the retreatment group B2,patients who were not effective (SD or PD) after 2 chemo-therapy cycles were administered with NP regimen for 2 cycles.Patients were administered with TP regimen for 2 cycles of retreat-ment(previous chemotherapy with DF regimen ).Patients who were not effective(SD or PD) after 2 chemotherapy cycles were ad-ministered with NP regimen for 2 cycles.Every 21days was a cycle .Results The effective rates of the 2 initial treatment groups (DF and TP) was similar(P>0.05),the toxicities of leucocyte and hemoglobin had no significant difference (P>0.05).The effective rates of patients who fisrt received DF regimen and retreated with NP and TP regimen were 42.5%and 45.0%respec-tively.Oppositely,patients who were administered with TP/NP regimen was replace NP/TP regimen,and their effective rates was lower than 10.0%.2Median time to progression was 5.3 months with TP regimen of initial treatment .Conclusion The NP and TP regimens of second-line using are more effective .
出处
《实用癌症杂志》
2014年第1期45-47,共3页
The Practical Journal of Cancer
基金
玉林市科技攻关项目(13036005)
关键词
鼻咽癌肺转移
化疗
DF方案
NP方案
TP方案
Nasopharyngeal carcinoma with lung metastasis
Chemotheraphy
DF regimen
NP regimen
TP regimen
