摘要
目的:研究布洛芬水溶性凝胶的最佳制备工艺。方法:以正交试验方法筛选基质最佳处方。结果:最佳基质处方为泊洛沙姆P407/P188(15%:20%)、海藻酸钠0.6%、乙醇15%,由此制得的布洛芬水溶性凝胶在体温下胶凝,粘度适中。结论:该处方设计合理,制备工艺稳定。
Objective:To study the optimal process of preparation of ibuprofen water-soluble gel Methods:Screen out the optimal formula of the matrix with the method of orthogonal experiment.Results:The optimal formula of the matrix is: Poloxamer P407/P188(15%:20%),sodium alginate(0.6%),alcohol(15%).The ibuprofen water-soluble gel prepared according to the optimal formula gelatinizes under the body temperature,and the viscosity is suitable.Conclusion:the formula is designed reasonably and the preparation process is stable.
出处
《黑龙江医药》
CAS
2009年第6期841-842,共2页
Heilongjiang Medicine journal
