摘要
目的观察丹红注射液对2型糖尿病肾病患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)的影响,探讨丹红注射液治疗2型糖尿病肾病的可能机制。方法采用常规西药加丹红注射液治疗30例2型糖尿病肾病患者为治疗组,取常规西药组30例作为对照组观察,于治疗前后检测患者血液中炎性因子CRP、TNF-α水平。结果丹红注射液治疗2型糖尿病肾病总有效率66.7%,而对照组总有效率为43.3%,两组比较差异有统计学意义(P<0.05);治疗前治疗组CRP、TNF-α水平与对照组比较差异无统计学意义(P>0.05);治疗后治疗组CRP、TNF-α显著降低,与对照组比较差异有统计学意义(P<0.05);治疗组治疗前和治疗后24h尿蛋白量下降与CRP、TNF-α水平呈正相关。结论丹红注射液结合西医治疗对2型糖尿病肾病有效,可能与丹红注射液能调节炎性因子的产生,抑制炎性反应有关。
Objective To observe the effect of Danhong injection on CRP、TNF-α in the patients with type-2 diabetic nephropathy and to study the curing mechanism of Danhong injection to diabetic nephropathy.Methods The 30 patients with type-2 diabetic nephropathy were treated with Danhong injection and routine drugs were treatment group.The other 30 diabetic nephropathy patients remedied routinely were the contrast group. The levels of CRP、TNF-α in the blood of patients were tested both before the treatment and after the cure courses.Results The total utility rate(66.7%) of Danhong injection to diabetic nephropathy was significantly higher than that of contrast group(43.3%). After the treatment the levels of CRP、TNF-α in the group treated with Danhong injection were lower than the control group. The decreasing of 24 h urine protein in Danhong injection group were lower and were positively correlated to CRP、TNF-α.Conclusion Danhong injection have significant treatment effect on the patients with type-2 diabetic nephropathy. The curing mechanism of Danhong injection to diabetic nephropathy may be the traditional Chinese medicine can regulate the production of inflammatory factors and can inhibit inflammatory reaction.
出处
《中国实用医药》
2007年第35期68-70,共3页
China Practical Medicine
