期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

水孔蛋白质的研究现状及与脑水肿的关系

Research Status of Aquaporins and the Relationship with Brain Edema
在线阅读 下载PDF
导出
摘要 水孔蛋白质(aquaporin,AQP)又称水通道蛋白(water channel protein),是一组与水跨膜转运有关的蛋白质。AQP-4是水孔蛋白质家族成员之一,仅对水分子有通透性,在脑组织中广泛存在并表达于血-脑屏障(blood brain barrier,BBB)处的星形胶质细胞膜,以及与脑脊液(cerebrospinal fluid,CSF)接触的软脑膜及室管膜表面。大量研究表明AQP-4在脑外伤、感染、肿瘤、卒中等中枢神经系统疾病引起的脑水肿中起关键作用。本文对AQP的分布、结构、功能及AQP-4与脑水肿的关系进行了综述。 Aquaporin(AQP)which is called water channel protein, is related to water transport across membrane. AQP-4 that can only transport water is one of the most important AQP expressed in the brain. AQP-4 is expressed in astroglia cells at the blood brain barrier (BBB) and in ependymal and piamatral surfaces contacted with cerebrospinal fluid (CSF). Many studies have testifi ed that AQP-4 is closely associated with the onset and development of brain edema in cerebral diseases, such as cerebral ischemia, tumor, traumetic injury, inflammatory diseases and so on. This article reviews the distribution and structure of AQP, as well as the relationship between AQP-4 and brain edema.
作者 狄楠 张祥建
机构地区 河北医科大学第二医院神经内科
出处 《中国卒中杂志》 2008年第6期453-459,共7页 Chinese Journal of Stroke
基金 河北省自然科学基金项目(C2006000915)
关键词 水孔蛋白质 脑水肿 Aquaporin Brain edema
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献39

  • 1[1]Preston GM,Agre P.Isolation of the cDNA for erythrocyte intergral membrane protein of 28 kilodoltous:member of an ancient channel famiily[J].Proc Natl Acad Sci USA,1991,8:11110-11114.
  • 2[2]Ishibashi K,Kuwahara M,Gu Y,et al.Aquaporin water channel role in vasopressin activated water transport[J].Bioehem Biophys Res Comma,1998,224:268-274.
  • 3[3]Cheng A,Van Hoek AN,Yeager M,et al.Threedimensional organization of a human water channel[J].Nature,1997,387:627-630.
  • 4[4]Echevarria M,IIundain AA.Aquaporins[J].Physiol Biochem,1998,4:107-118.
  • 5[5]Ma T,Song Y,Yang B,et al.Nephrogenic diabetes insipidus in micedeficient in AQP3 water channel[J].Proc Natl Acad Sci USA,2000,97:4386-4391.
  • 6[6]Yang B,Giltespie A,Carlson EJ,et al.Early neonatal mortality in a transgcneic AQP2 knock-in model nephrogenic diabetes insipidus[J].Biol Chem,1998,273:2775-2779.
  • 7[7]Deen PM,Vcrkijk MA,Knoers NV,et al.Requirement of human ranel water channel aquaporin-2 for vasopressin-dependent concentration of urine[J].Science,1994,264:92-95.
  • 8[8]Ma T,Hara M,Sougrat R,et al.Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3[J].Biol Chem,2002,277:17147-17153.
  • 9[9]Hara M,Ma T,Verkman AS.Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration,elasticity,and barrier recovery[J].Biol Chem,2001,276:23413-23420.
  • 10[10]Krane CM,Melvin JE,Nguyen HV,et al.Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation[J].Biol Chem,2001,276:23413-23420.

二级参考文献11

  • 1Taniguchi M, Yamashita T, Kumura E, et al. Induction of aquaporin - 4 water channel mRNA after focal cerebral ischemia in rat[J]. Brain Res Mol Brain Res, 2000,78(1 -2):131 - 137.
  • 2Yang G Y, Betz A L, Chenevert T L, et al. Experimental intracerebral hemorrhage: relationship between brain edema,blood flow, and blood brain- barrier permeability in rats [J].J Neurosurg, 1994,81:93- 102.
  • 3Mcndelow A D. Mechanisms of ischemic brain damage with intracerebral hemorrhage [J]. Stroke, 1993,24 : 1 - 115.
  • 4Rosenberg G A, Mun- Bryce S, Wesley M, et al. Collagenase induced intracerebral hemorrhage in rats[J]. Stroke, 1990,21: 802 - 807.
  • 5Manley G T, Fujimura M, Ma T, et al. Aquaporin -4 deletion in mice reduces brain edema after acute water ntoxication and ischemic stroke[J]. Nat Med, 2000,6(2):159-163.
  • 6King L S, Agre P. Pathophysiology of the aquaporin water channels[J]. Annu Rev Physiol, 1996,58:619 - 622.
  • 7Yamamoto N, Yoneda K, Asai K, et al. Alteration in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation [J]. Brain Res Mol Rrain Res,2001,90(1):26 - 38.
  • 8Xi G, Keep R F, Hoff J T. Erythrocytes and delayed brain edema following intracerebral hemorrhage in rats [J].J Neurosurg,1998,89:991 - 996.
  • 9Lee K R, Kawai N, Kim S, et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral flood flow, blood - brain barrier permeability,and cell survival in rat model [J]. J Neurosurg, 1997,86 (2) : 272 -278.
  • 10许志强,陈曼娥,蒋晓江,王景周.脑出血血肿周边及下丘脑去甲肾上腺素含量变化的实验研究[J].中国危重病急救医学,2002,14(1):41-43. 被引量：9

共引文献40

中国卒中杂志
2008年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部