摘要
目的:探讨慢性阻塞性肺疾病急性加重(AECOPD)患者治疗前后血IL-10、IL-23、CRP等炎症因子的浓度变化及其与肺功能损害的相关性。方法:采用ELISA分析30例AECOPD患者治疗前后血清IL-10、IL-23、C-反应蛋白,测PaO2、FEV1(、FEV1/FVC%、外周血白细胞计数和中性粒细胞百分比,分析IL-10、IL-23、CRP与FEV1(和FEV1/FVC%的相关性。结果:在AECOPD患者中,治疗前后IL-10浓度分别为(179.9±73.8 pg/L)和(223.5±107.8 pg/L),比对照组(364.3±160.2pg/L)低;治疗前后IL-23浓度分别为(189.4±103.7 pg/L)和(177.2±103.2 pg/L),均比对照组(89.7±64.4pg/L)高;治疗前后CRP浓度分别为(24.1±18.2mg/L)和(10.2±4.6 mg/L),均比对照组(5.6±1.9 mg/L)高;差异均有统计学意义。IL-10浓度与FEV1、FEV1/FVC变化呈正相关(r=0.782,r=0.575,P<0.05);IL-23浓度与FEV1、FEV1/FVC呈负相关(r=-0.586,r=-0.453,P<0.05);CRP浓度与FEV1、FEV1/FVC呈负相关(r=-0.725,r=-0.643,P<0.05)。结论:AECOPD患者血IL-10浓度较对照组低,而IL-23和CRP浓度较对照组高;血IL-10、IL-23和CRP的浓度与肺功能损害程度相关。
Objective:To investigate the changes of Interleukin-10(IL-10),Interleukin-23(IL-23) and C-reactive protein(CRP) levels in patients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD) and to analyze the correlation between the inflammatory factor and COPD.Methods:The levels of IL-10,IL-23 and CRP in thirty cases of patients with AECOPD were measured by enzyme-linked immunosorbent assay.The amounts of neutrophils,PaO2 and lung function indexes such as the forced expiratory volume in one...
出处
《华西医学》
CAS
2008年第5期1049-1051,共3页
West China Medical Journal
