摘要
目的 探讨胸椎旁神经阻滞对胸腔镜肺癌根治术患者镇痛效果及血清肿瘤标志物的影响.方法 选择2015年12月至2017年12月行胸腔镜肺癌根治术的肺癌患者86例,按照随机数字表法分为观察组与对照组,各 43例.对照组麻醉诱导前不进行任何处理,观察组于麻醉诱导前行胸椎旁神经阻滞.比较两组阻滞1h、24h、48h和出院时VAS评分,术后24h和术后48h自控静脉镇痛泵按压次数,术前和术后24h血清肿瘤标志物变化,术后不良反应情况.结果 两组患者阻滞1h、24h、48h、出院时VAS评分低于阻滞前,差异有统计学意义(P<0.05);观察组阻滞1h、24h、48h、出院时VAS评分低于对照组,差异有统计学意义(P<0.05).观察组术后24h、48h自控静脉镇痛泵按压次数少于对照组,差异有统计学意义(P<0.05).两组术后24h SCC、CA125和CEA水平比较差异无统计学意义(P>0.05).两组术后不良反应发生率比较差异无统计学意义(P>0.05).结论 胸椎旁神经阻滞对胸腔镜肺癌根治术患者镇痛效果明显,对血清肿瘤标志物SCC、CA125和CEA无明显影响.
Objective To investigate the effect of thoracic paravertebral nerve block on the analgesic effect and serum tumor markers in patients undergoing thoracoscopic radical resection of lung cancer. Methods From December 2015 to December 2017,86 cases of lung cancer patients who underwent thoracoscopic radical resection of lung cancer were selected. They were divided into observation group(43 cases)and control group(43 cases)according to random number table. The control group received no treatment before the induction of anesthesia,and the observation group received thoracic paravertebral nerve block before anesthesia induction. The two groups were compared to block 1H,block 24h,block 48h and at discharge the VAS score. The number of press times of 24h and 48h self controlled intravenous analgesia pump after operation,and the changes of serum tumor markers before and after the operation were compared,postoperative adverse reaction. Results The two groups of block 1h,block 24h,block 48h,discharge VAS score were lower than that before anesthesia(P<0.05), the observation group block 1h,block 24h,block 48h,,discharge VAS score lower than the control group(P<0.05). The number of postoperative 24h and 48h patient-controlled intravenous analgesia pump in the observation group was less than that in the control group(P<0.05). The preoperative SCC,CA125 and CEA were not statistically different between the two groups(P>0.05). There was no significant difference in the levels of 24h,SCC,CA125 and CEA between the two groups(P>0.05). There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Thoracic paravertebral nerve block has obvious analgesic effect on patients undergoing thoracoscopic radical resection of lung cancer,and has no significant effect on serum tumor markers SCC,CA125 and CEA.
出处
《浙江临床医学》
2019年第3期401-403,共3页
Zhejiang Clinical Medical Journal
关键词
胸椎旁神经阻滞
胸腔镜肺癌根治术
镇痛
血清肿瘤标志物
Thoracic nerve block
Thoracoscopic lung cancer radical surgery
Analgesia
Serum tumor markers
