摘要
目的:探讨成年男性阻塞性睡眠呼吸暂停(OSA)患者血清神经肽Y(NPY)水平与微觉醒的相关性。方法:通过多导睡眠图(PSG)确诊为OSA的32例成年男性患者进行严重程度评估,根据根据睡眠呼吸暂停低通气指数(AHI)将患者分为轻度组(n=4例)、中度组(n=4例)及重度组(n=24例);32例健康自愿者作为对照组。采用酶联免疫吸附法(ELISA)检测所有受试者血清NPY水平;通过Epworth嗜睡量表(ESS)评估受试者白天嗜睡程度,比较并分析不同程度OSA患者及健康者各种数据的差别;分析不同程度OSA患者间的各种数据的差别;将OSA患者血清NPY水平与患者微觉醒进行相关性分析。结果:OSA各组与对照组相比年龄差别无统计学意义。而血清NPY水平、ESS评分、BMI具有显著差别,差别具有统计学意义。轻度组与中度组间只有AHI差异有统计学意义,轻度组与重度组间血清NPY水平、BMI、AHI、微觉醒指数(MAI)差异均有统计学意义,而与对照组相比只有ESS评分差异有统计学意义。中度组与重度组间血清NPY水平、AHI差异有统计学意义。重度组与对照组间血清NPY水平、ESS评分差异均有统计学意义(血清NPY水平)。中度组与对照组间血清NPY水平、BMI差异无统计学意义。OSA患者血清NPY水平与MAI呈正相关,血清NPY与AHI、BMI及ESS评分均呈正相关。而BMI与MAI无显著相关性。MAI除与血清NPY相关外还与AHI呈强相关性。结论:OSA患者的血清NPY水平会增高,OSA患者血清NPY水平与MAI、AHI及BMI有关,随着OSA患者病情的加重,患者夜间会频发微觉醒,血清NPY水平也会因微觉醒次数的增加而升高。血清NPY水平有望成为反映OSA患者微觉醒的生物学标志。
Objective To explore the correlation between serum neuropeptide Y(NPY)level and micro-arousal in adult male patients with obstructive sleep apnea(OSA).Methods Thirty-two adult male patients diagnosed as OSA by polysomnography(PSG)were assessed for severity.According to sleep apnea hypopnea index(AHI),the patients were divided into mild group(n=4 cases),moderate group(n=4 cases)and severe group(n=24 cases),and 32 healthy volunteers as control group.Serum NPY levels were measured by ELISA;daytime sleepiness was assessed by Epworth Sleepiness Scale(ESS),and the differences of data between OSA patients and healthy persons were compared and analyzed;the differences of data between OSA patients of different degrees were analyzed;the correlation between serum NPY levels of OSA patients and patients'micro-awakening was analyzed.Results There was no significant difference in age between OSA group and control group.Serum NPY level,ESS score and BMI were significantly different.There was only significant difference in AHI between mild group and moderate group.There were significant differences in serum NPY level,BMI,AHI and MAI between mild group and severe group,while there was only significant difference in ESS score between mild group and severe group.There were significant differences in serum NPY level and AHI between moderate and severe groups.There were significant differences in serum NPY level and ESS score between severe group and control group(serum NPY level).There was no significant difference in serum NPY level and BMI between moderate group and control group.Serum NPY level was positively correlated with MAI in OSA patients,and serum NPY was positively correlated with AHI,BMI and ESS scores.There was no significant correlation between BMI and MAI.In addition to serum NPY,MAI was strongly correlated with AHI.Conclusions Serum NPY level in OSA patients will increase.Serum NPY level in OSA patients is related to MAI,AHI and BMI.With the aggravation of OSA patients'condition,patients will frequently wake up at night,and serum NPY level will increase with the increase of the number of micro-awakening.Serum NPY level is expected to be a biological marker reflecting micro-arousal in OSA patients.
作者
朱明
卢静成
段宗瑾
颜红
Zhu Ming;Lu Jing-cheng;Duan Zong-jin;Yan Hong(Anhui Huainan the First People's Hospital,Huainan 232007,China)
出处
《晓庄学院学报（医学版）》
2019年第6期147-150,共4页
Journal of Hunan Normal University(Medical Sciences)
