摘要
目的分析广州市番禺区中心医院收治的登革热患者特征,了解本区域登革热流行态势,为登革热预防和治疗提供一定的方法和指导。方法回顾性分析2015年1月-2019年12月广州市番禺区中心医院收治的598例登革热患者性别、年龄、时间、空间分布等流行病学资料、临床特征及抗体检查和核酸检测结果等。结果2015-2019年登革热患者男女性别构成比差异无统计学意义(P=0.055),年龄分布差异无统计学意义(P=0.958)。2015-2016年病例较少,2017年病例明显增加,2017-2018年登革热病例数均在10月达到高峰期,2019年病例数在9月达到高峰,后逐月下降。2015-2019年登革热患者主要集中在本区的洛浦(28.26%)、市桥(20.07%)和桥南街(12.54%);患者职业主要为家务及待业(36.12%)、其次为职业不详人员(22.41%)和农民(12.88%);2015-2019年登革热患者主要临床表现为发热(95.82%)、上呼吸道感染(19.40%)、皮疹(10.70%),2015-2019年登革热患者NS1抗原阳性比例最高(79.76%),NS1抗原、IgG、IgM抗体阳性结果分类构成比例差异有统计学意义(P=0.000);本区登革热患者核酸分型仍以1型为主(88.37%),少量2、3型病例,无4型病例及合并感染。结论2017-2019年本区域登革热患者呈增多趋势,本地病例和输入病例并存,核酸分型以1型为主,本区域登革热疫情严峻。
Objective To analyze the characteristics of dengue patients in Panyu District Central Hospital of Guangzhou,find out the epidemic situation of dengue in this region,and provide some methods and guidance for dengue prevention and treatment.Methods From January 2015 to December 2019,598 cases of dengue fever in Panyu District Central Hospital of Guangzhou City were analyzed retrospectively in terms of epidemiological data,clinical characteristics,antibody test and nucleic acid test results,such as gender,age,time and spatial distribution.Results There was no difference in the gender ratio of dengue fever patients between 2015 and 2019(P=0.055),and there was no difference in the age distribution(P=0.958).From 2015 to 2016,there were fewer cases,and the number of cases increased significantly in 2017.From2017 to 2018,the number of dengue fever cases peaked in October,and in 2019,the number of dengue fever cases peaked in September,and then declined month by month.From 2015 to 2019,dengue patients were mainly concentrated in Luopu(28.26%),Shiqiao(20.07%)and Qiaonan(12.54%);the main occupations of patients were housework and waiting for work(36.12%),followed by unknown workers(22.41%)and farmers(12.88%);the main clinical manifestations of dengue patients from 2015 to 2019 were fever(95.82%),upper respiratory tract infection(19.40%)and rash(10.70%).From 2015 to 2019,the proportion of NS1 antigen positive in dengue patients was the highest(79.76%),and the difference in the proportion of NS1 antigen,IgG and IgM antibody positive was statistically significant(P=0.000);the nucleic acid typing of dengue patients in this area was still mainly type 1(88.37%),a small number of type 2 and type 3 cases,no type4 cases and co infection.Conclusion From 2017 to 2019,the number of cases of dengue fever in the region increased;local cases and imported cases coexisted,type 1 dengue virus was the dominant type,and the epidemic situation of dengue fever in the region was still severe.
作者
杨晓燕
聂俊峰
赵莹
廖利银
郭仲辉
YANG Xiao⁃yan;NIE Jun⁃feng;ZHAO Ying;LIAO Li⁃yin;GUO Zhong⁃hui(Department of Clinical Laboratory,Panyu District Central Hospital of Guangzhou City,Guangzhou,Guangdong 511400;Medical Department,Panyu District Central Hospital of Guangzhou City,Guangzhou,Guangdong 511400,China)
出处
《热带医学杂志》
CAS
2021年第12期1597-1600,共4页
Journal of Tropical Medicine
基金
广州市番禺区科技工业商务和信息化局资助项目(2017-Z04-21)
关键词
登革热
登革病毒
感染
Dengue fever
Dengue virus
Infection
