摘要
目的探究维生素D水平与代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)间的关系,分析维生素D缺乏合并糖尿病、肥胖/超重、高甘油三酯血症对MAFLD的影响。方法对内蒙古民族大学附属医院2017年1月至2023年4月收治的375例接受维生素D检测的患者进行回顾性分析,按腹部超声有无诊断脂肪肝将其分为MAFLD组196例和非MAFLD组179例。正态分布的计量资料两组间比较采用t检验;非正态分布的计量资料两组间比较采用Mann-Whitney U秩和检验;计数资料组间比较采用χ^(2)检验;MAFLD的危险因素分析采用二元logistic回归分析。结果与非MAFLD组相比,MAFLD组的体质量指数(body mass index,BMI)(Z=-11.028)、收缩压(Z=-2.161)、舒张压(Z=-4.747)、甘油三酯(triglyceride,TG)(Z=-4.673)、空腹血糖(Z=-4.964)、天门冬氨酸氨基转移酶(aspartate aminotrans-ferase,AST)(Z=-5.705)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)(Z=-5.162)、γ-谷氨酰基转移酶(gamma-glutamyltransferase,GGT)(Z=-3.998)水平,以及男性(χ^(2)=8.796)、高血压(χ^(2)=52.988)、糖尿病(χ^(2)=15.718)、超重/肥胖(χ^(2)=-11.028)、甘油三酯(χ^(2)=-4.673)、维生素D缺乏(χ^(2)=147.174)的比例均较高(P<0.05)。logistic回归结果显示,高低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)(OR=2.706,95%CI:1.118~6.812)、维生素D缺乏(OR=13.768,95%CI:7.463~24.402)、高血压(OR=2.636,95%CI:1.224~5.680)、糖尿病(OR=2.135,95%CI:1.050~4.340)、超重/肥胖(OR=1.342,95%CI:1.210~1.487)、高甘油三酯血症(OR=1.496,95%CI:1.083~2.068)是MAFLD发生的危险因素(P<0.05)。二元logistic回归分析结果提示,维生素D缺乏可增加糖尿病、超重/肥胖、高甘油三酯血症受试者的MAFLD发病风险(OR=49.907、319.231、38.000,P<0.005)。结论维生素D水平与MAFLD的发病风险有关,合并糖尿病、肥胖/超重、高甘油三酯血症可能进一步增加MAFLD的发生。
Objective This study aims to investigate the relationship between vitamin D(VD)levels and metabolic-associated fatty liver disease(MAFLD)and analyze the impact of vitamin D deficiency on MAFLD when combined with diabetes,obesity/overweight,and hypertriglyceridemia.Methods A retrospective analysis was conducted on 375 patients who underwent vitamin D testing at Inner Mongolia University for Nationalities Affiliated Hospital from January 2017 to April 2023,patients were categorized into the MAFLD group(n=196)and the non-MAFLD group(n=179)based on abdominal ultrasound diagnosis of fatty liver.Group comparisons for normally distributed continuous variables were performed using independent samples t-test;non-normally distributed continuous variables were compared using the Mann-Whitney U test;and categorical data were compared using the chi-square test.Binary logistic regression analysis was employed to identify risk factors for MAFLD.Results Compared with the non-fatty liver group,the MAFLD group exhibited higher levels of BMI(Z=-11.028),systolic blood pressure(Z=-2.161),diastolic blood pressure(Z=-4.747),triglycerides(TG)(Z=-4.673),fasting blood glucose(Z=-4.964),AST(Z=-5.705),ALT(Z=-5.162),GGT(Z=-3.998),as well as a higher proportion of males(χ^(2)=8.796),hypertension(χ^(2)=52.988),diabetes(χ^(2)=15.718),overweight/obesity(χ^(2)=-11.028),triglyceride elevation(χ^(2)=-4.673),and vitamin D deficiency(χ^(2)=147.174)(P<0.05).logistic regression results showed that LDL-C(OR=2.706,95%CI:1.118-6.812),vitamin D deficiency(OR=13.768,95%CI:7.463-24.402),hypertension(OR=2.636,95%CI:1.224-5.680),diabetes(OR=2.135,95%CI:1.050-4.340),overweight/obesity(OR=1.342,95%CI:1.210-1.487),and hypertriglyceridemia(OR=1.496,95%CI:1.083-2.068)were risk factors for MAFLD(P<0.05).Binary logistic regression analysis suggested that vitamin D deficiency increased the risk of MAFLD in subjects with diabetes,overweight/obesity,and hypertriglyceridemia(OR=49.907,319.231,38.000;P<0.005).Conclusion Vitamin D levels are associated with the risk of MAFLD,Vitamin D deficiency combined with diabetes,obesity/overweight,and high triglycerides may further increase the occurrence of MAFLD.
作者
杜晓旭
包萨如拉
冯帆
戈宏焱
DU Xiao-xu;BAO Saru-la;FENG Fan;GE Hong-yan(School of Clinical Medicine,Inner Mongolia Minzu University,Tongliao,Inner Mongolia 028000,China;不详)
出处
《慢性病学杂志》
2024年第6期801-806,共6页
Chronic Pathematology Journal
基金
内蒙古自治区直属高校基本科研业务项目(GXKY23Z044)
