摘要
目的:探讨小儿定喘口服液联合氨茶碱治疗小儿支气管哮喘的疗效及对患儿血清免疫球蛋白(IgG、IgA、IgE、IgM)、嗜酸性粒细胞阳离子蛋白(ECP)、嗜酸性粒细胞(EOS)的影响。方法:选取2016年5月—2017年11月我院收治的小儿支气管哮喘患儿92例,采用随机数字表法分为观察组和对照组,各46例,同期选择我院健康体检儿46例作为正常组。对照组给予氨茶碱治疗,观察组在对照组基础上加用小儿定喘口服液治疗,两组均治疗2周。比较两组患儿的临床疗效及4月内复发率,同时比较三组治疗前后血清IgG、IgA、IgE、IgM、ECP、EOS水平。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后观察组IgG、IgA、IgM水平均高于对照组,IgE水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组ECP、EOS水平较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05);随访4个月,观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论:小儿定喘口服液联合氨茶碱治疗小儿支气管哮喘的效果良好,可调节患儿的细胞免疫和体液免疫功能,减少复发,值得临床推广使用。
Objective:To explore the efficacy of xiaoer dingchuan oral liquid combined with aminophylline in the treatment of bronchial asthma in children and its effect on serum immunoglobulins(IgG,IgA,IgE,IgM)and eosinophil cationic protein(ECP)and eosinophils(EOS).Methods:92 children with bronchial asthma admitted to our hospital from May 2016 to November 2017 were selected and randomly divided into an observation group and a control group,46 cases each.46 children undergoing health examination were used as a normal group.The patients in the control group were treated with aminophylline,and the patients in the observation group were treated with xiaoer dingchuan oral liquid on the basis of the treatment in the control group.The children in the two groups were treated for 2 weeks.The clinical efficacy,recurrence rate within 4 months and the serum levels of IgG,IgA,IgE,IgM,ECP and EOS before and after treatment were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IgG,IgA and IgM in the observation group were higher than those in the control group,and the level of IgE was lower than that in the control group,with statistically significant differences(P<0.05).The levels of ECP and EOS after treatment were lower than those before treatment in the two groups,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After 4 months of follow-up,the recurrence rate in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Xiaoer dingchuan oral liquid combined withaminophylline has a good effect in the treatment of bronchial asthma in children,which can regulate the cellular immunity and humoral immune function of the children and reduce recurrence,and is worthy of clinical promotion.
作者
胡博
王小稳
Hu Bo;Wang Xiao-wen(West District Emergency Department,Zhengzhou Children’s Hospital,Zhengzhou,Henan 450000,China)
出处
《中国合理用药探索》
CAS
2019年第11期25-27,31,共4页
Chinese Journal of Rational Drug Use
