In order to identify family factors obviously relevant to aggression, and offer a theoretical foundation for the prevention of aggression, 4010 students from primary and secondary schools in 5 different areas in Hubei...In order to identify family factors obviously relevant to aggression, and offer a theoretical foundation for the prevention of aggression, 4010 students from primary and secondary schools in 5 different areas in Hubei province were surveyed. The Child Behavior Checklist ＂ parents＂ form＂ （Chinese version） and the four scales of Family Environment Scale were used. A multiple logistic regression was used to identify risk factors of children＇s and adolescents＂ aggressive behavior. The results showed that maternal education, paternal occupation, family type, parental child-rearing attitude and patterns, students＂ interpersonal relationship were significantly associated with the childreffs and adolescents＂ aggression. The risk factors of aggression were parental child-rearing patterns, peer relationship, teacher-student relationship, and family conflicts.展开更多
To understand the prevalence and rehabilitation status of autism and mental retardation in China. Methods Screening test and clinical assessment were conducted for the diagnosis of autism and mental retardation. The a...To understand the prevalence and rehabilitation status of autism and mental retardation in China. Methods Screening test and clinical assessment were conducted for the diagnosis of autism and mental retardation. The assessment included investigation of the histories of medical conditions and development of these two disorders, utilization and needs for the rehabilitation service, and related intellectual and behavioral appraisal. Results Among the 7345 children investigated, the prevalence of autism disorder was 1.10 cases per 1000 children aged 2-6 years （95% CI=0.34 to 2.54）, and the prevalence of mental retardation was 10.76 cases per 1000 children （95% CI=8.40 to 13.12）. All the children suffering from autistic disorder were intellectually disabled, whereas 31.0% of the non-autism mental retardates had other disabilities. The medical conditions prior to birth and perinatal period were important potential factors for autism. Half of the autistic children and 84% of the children with non-autism mental retardation had never received any rehabilitative service. Conclusions The prevalence of autistic disorder in children aged 2-6 years in Tianjin is rather high. It is urgent to improve the status of the autistic and intelligently disabled young children in China. In order to upgrade the level of early diagnostic and improve the intervention to autism and mental retardation, public awareness and training courses should be heightened.展开更多
Objective To explore the endocfinal factors which influence the aggressive behavior of adolescents. Methods The levels of cortisol （CORT）, testosterone （T）, prolactin （PRL）, and growth hormone （GH） in saliva f...Objective To explore the endocfinal factors which influence the aggressive behavior of adolescents. Methods The levels of cortisol （CORT）, testosterone （T）, prolactin （PRL）, and growth hormone （GH） in saliva from 20 aggressive students and 20 non-aggressive control students were measured by radioimmunoassay （RIA）. The students were matched for their gender, age, grade, stage of pubertal development, and economic status of their families. Results The salivary T levels were 22.20±14.50 pg/mL and 19.54±12.52 pg/mL in aggressive male and female students, 13.20±6.85 pg/mL and 5.24±3.03 pg/mL in non-aggressive male and female students （P〈0.05）. The male aggressive students had a lower level of CORT in saliva than non-aggressive male students （P〈0.05）. There were no significant differences in the salivary levels of PRL or GH between the aggressive and non-aggressive groups. Correlation analysis revealed a negative relationship in male students between the salivary CORT levels and the aggression factor scores of the child behavior checklist （CBCL）. In addition, the data also showed a positive relationship between the salivary T levels and the aggression factor scores of CBCL in female students. Multiple linear regression analysis showed that the salivary CORT level was an independent predictive factor for aggressive behaviors in adolescent boys. The higher the CORT level, the less aggressive the boys were. Conclusion CORT and T levels may play a certain role in adolescent aggressive behaviors.展开更多
Objective The aim of this study was to analyze the mediating effect of body dissatisfaction in correlation between obesity and dietary behavior changes for weight loss(DBCWL).Methods A total of 680 primary and middle ...Objective The aim of this study was to analyze the mediating effect of body dissatisfaction in correlation between obesity and dietary behavior changes for weight loss(DBCWL).Methods A total of 680 primary and middle school students were included in this study. Their body height, weight, and waistline were effectively measured, and they were also evaluated to assess their body dissatisfaction, perception of dietary behaviors, and DBCWL. The correlation among these factors was analyzed using mediating effect models.Results The prevalence of overweight/obesity and abdominal obesity was significantly higher in males than in females(P < 0.05). Overweight/obesity, abdominal obesity, and body dissatisfaction significantly increased the risk for DBCWL(OR = 2.57, 2.77, and 1.95, respectively). Overweight/obesity and abdominal obesity significantly increased the risk for body dissatisfaction(OR = 6.00 and 4.70,respectively). Significant mediating effects of body dissatisfaction were observed in correlation between overweight/obesity and DBCWL and between abdominal obesity and DBCWL(OR = 2.20 and 1.92,respectively;P < 0.05), and the proportions of mediating effects among the total effects were 48.89% and 46.60%, respectively.Conclusion Body dissatisfaction might play an important mediating effect in association between DBCWL and obesity, which indicates that guiding children to correctly recognize their body might be more conducive than promoting obese children toward weight loss through dietary behavior changes.展开更多
Rats were exposed to1 or 10 μg/mL bisphenol A （BPA） in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day （PND） 50. Perinatal exposure t...Rats were exposed to1 or 10 μg/mL bisphenol A （BPA） in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day （PND） 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin （ADP） levels in both female and male offspring rats. Liver adipose triglyceride lipase （Atgl） mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.展开更多
Inhibitory ability of children with developmental dyscalculia（DD） was investigated to explore the cognitive mechanism underlying DD.According to the definition of developmental dyscalculia,19 children with DD-only a...Inhibitory ability of children with developmental dyscalculia（DD） was investigated to explore the cognitive mechanism underlying DD.According to the definition of developmental dyscalculia,19 children with DD-only and 10 children with DD＆RD（DD combined with reading disability） were selected step by step,children in two control groups were matched with children in case groups by gender and age,and the match ratio was 1：1.Psychological testing software named DMDX was used to measure inhibitory ability of the subjects.The differences of reaction time in number Stroop tasks and differences of accuracy in incongruent condition of color-word Stroop tasks and object inhibition tasks between DD-only children and their controls reached significant levels（P〈0.05）,and the differences of reaction time in number Stroop tasks between dyscalculic and normal children did not disappear after controlling the non-executive components.The difference of accuracy in color-word incongruent tasks between children with DD＆RD and normal children reached significant levels（P〈0.05）.Children with DD-only confronted with general inhibitory deficits,while children with DD＆RD confronted with word inhibitory deficits only.展开更多
To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to ...To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to pass the universal newborn hearing screening （UNHS） were referred to Jinan Newborn Hearing Screening and Rehabilitation Center from 7 newborn hearing screening centers in seven cities of Shandong province. One-to-one pair-matched case-control method was employed for statistical analysis of the basic features of definitely identified cases. High-risk factors relating to the bilateral hearing loss were evaluated by univariate and multivariate Logistic regression analysis. Our results revealed that 721 transferred newborns who didn＇t pass the heating screening received audiological and medical evaluation and 367 were confirmed to have hearing loss. Of them, 177 neonates with hearing loss who met the matching requirements were included in the study as subjects. Univariate analysis showed that high-risk factors related to hearing loss incuded age of father, education backgrounds of parents, parity, birth weight, gestational weeks, craniofacial deformity, history of receiving treatment in neonatal intensive care unit （NICU）, neonatal disease, family history of otopathy and family history of congenital hearing loss. Multivariate Logistic regression analysis revealed that 4 independent risk factors were related to bilateral hearing loss, including parity （OR=16.285, 95% CI 3.379--78,481）, neonatal disease （OR=34;968, 95% CI 2.720 449.534）, family history of congenital hearing loss （OR=69.488, 95% CI 4.417--1093.300） and birth weight （OR=0.241, 95% CI 0.090--0.648）. It is concluded that parity, neonatal disease and family history of heating loss are the promoting factors of bilateral hearing loss in neonates and appropriate intervention measures should be taken to deal with the risk factors.展开更多
What is already known about this topic?The prevalence of mental health disorders among children and youth in China stands at 17.5%,a figure that has been gradually escalating over recent years.This surge has led to su...What is already known about this topic?The prevalence of mental health disorders among children and youth in China stands at 17.5%,a figure that has been gradually escalating over recent years.This surge has led to substantial psychological distress and financial strain for both families and the wider society.What is added by this report?This study boasts an expansive geographical scope by covering the Jiangsu Province extensively and utilizing a substantial sample size.An investigation was conducted on the prevalence and risk factors,which included family type and health behaviors,of depressive,anxiety,and stress symptoms.What are the implications for public health practice?The mental health status of children and adolescents should be of great concern to the government.Therefore,it is important that public health measures are implemented to mitigate the development of depressive symptoms.These measures may include regular screening procedures and the implementation of proven interventions.展开更多
To assess the potential therapeutic effect of propofol in the treatment of endotoxemia, 76 rats were randomly assigned to 5 groups: control group(A), endotoxemic group(B), pre-treatment group(C), simultaneous treatmen...To assess the potential therapeutic effect of propofol in the treatment of endotoxemia, 76 rats were randomly assigned to 5 groups: control group(A), endotoxemic group(B), pre-treatment group(C), simultaneous treatment group(D) and post-treatment group(E) Five h after endotoxin injection, PO 2, pH, MAP, plasma concentrations of Nitrite/nitrate (NO - 2/NO - 3) and mortality rates were assessed in each group After the rats were sacrificed, lung tissue was sampled to measure myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-α contents It was found that endotoxin injection produced progressive hypotension, metabolic acidosis, and a large increase in the plasma NO - 2/NO - 3concentrations and increased mortality rates in 5h Endotoxin injection significantly increased MPO activity and TNF-α contents in lung tissue ( P <0 01 or P <0 05) These changes response to endotoxin were significantly attenuated in the groups B, C and D But these beneficial effects were blunted in the group E The results suggest that propofol administration may offer advantages in endotoxemia展开更多
studies have suggested that non-optimal temperatures may increase the risk of injury,epidemiological studies focusing on the association between temperature and non-fatal injury among children and adolescents are limi...studies have suggested that non-optimal temperatures may increase the risk of injury,epidemiological studies focusing on the association between temperature and non-fatal injury among children and adolescents are limited.Therefore,we investigated the short-term effect of ambient temperature on non-fatal falls and road traffic injuries(RTIs)among students across Jiangsu Province,China.Meteorological data and records of non-fatal outdoor injuries due to falls and RTIs among students aged 6–17 were collected during 2018–2020.We performed a time-stratified case-crossover analysis with a distributed lag nonlinear model to examine the effect of ambient temperature on the risk of injury.Individual meteorological exposure was estimated based on the address of the selected school.We also performed stratified analyses by sex,age,and area.A total of 57322 and 5455 cases of falls and RTIs were collected,respectively.We observed inverted U-shaped curves for temperatureinjury associations,with maximum risk temperatures at 18℃(48th of daily mean temperature distribution)for falls and 22℃(67th of daily mean temperature distribution)for RTIs.The corresponding odds ratios(95%confidence intervals)were 2.193(2.011,2.391)and 3.038(1.988,4.644)for falls and RTIs,respectively.Notably,there was a significant age-dependent trend in which the temperature effect on falls was greater in older students(P-trend<0.05).This study suggests a ignificant association between ambient temperature and students’outdoor falls and RTIs.Our findings may help advance tailored strategies to reduce the incidence of outdoor falls and RTIs in children and adolescents.展开更多
What is already known about this topic?Interventions aimed at modifying lifestyle behaviors can effectively reduce the risk of depression among adolescents.These lifestyle behaviors tend to be interconnected;thus,chan...What is already known about this topic?Interventions aimed at modifying lifestyle behaviors can effectively reduce the risk of depression among adolescents.These lifestyle behaviors tend to be interconnected;thus,changes to one behavior can often lead to changes in others,usually occurring simultaneously.What is added by this report?Adolescents from Jiangsu Province displayed distinct lifestyle patterns,with those engaging in multiple specific behaviors,such as excessive consumption of sugar-sweetened beverages and prolonged screen time,showing increased odds of depression.What are the implications for public health practice?Early implementation of anti-depression interventions in adolescents should be advocated and prioritized,particularly targeting multiple high-risk lifestyles.展开更多
There has been lack of studies that investigate the causal impact of alcohol consumption on health and mortality in middle-aged and older populations in China.This cohort study aims to investigate whether alcohol use ...There has been lack of studies that investigate the causal impact of alcohol consumption on health and mortality in middle-aged and older populations in China.This cohort study aims to investigate whether alcohol use increases poor health and mortality risk in middle-aged and older Chinese population.The study is a cohort study design that was based on the China Health and Retired Longitudinal study(CHARLS).Measures of poor health and alcohol use are self-rated poor/very poor and alcohol use.Competing Cox proportional hazard regression model(CPHM)was used to model the data and the hazards ratio(HR)of poor health,mortality for current and former drinkers versus nondrinkers and current drinkers versus former drinkers was estimated using CPHM after adjusting for deign-effects and covariates.This study found significantly increased risk of all-cause mortality among current(adjusted HR=1.54 and P=0.0423)and former drinkers(Adjusted HR=1.52 and P=0.0096)compared to lifetime nondrinkers among middle-aged and senior Chinese people;significantly increased hazard of poor health among current drinkers(Adjusted HR=1.26 and P=0.0443)compared with lifetime nondrinkers.The hazards of all-cause mortality and self-rated poor health increased with the amount and frequency of alcohol drinking,and drinking years.This study found that either former or current drinkers self-rated having a poor health and had a significantly increased risk of all-cause mortality compared with nondrinkers.Heavy drinkers had poor health status and higher risk of mortality compared with those who drank light or moderate amount of alcohol in middle-aged and senior Chinese population.展开更多
Childhood obesity has becoming an increasing concern in many countries including China [1-3].Located in the eastern China,Jiangsu Province is one of the developed regions in China and is also facing this problem.
Malformations of cortical development(MCD)are a group of developmental disorders characterized by abnormal cortical structures caused by genetic or harmful environmental factors.Many kinds of MCD are caused by genetic...Malformations of cortical development(MCD)are a group of developmental disorders characterized by abnormal cortical structures caused by genetic or harmful environmental factors.Many kinds of MCD are caused by genetic variation.MCD is the common cause of intellectual disability and intractable epilepsy.With rapid advances in imaging and sequencing technologies,the diagnostic rate of MCD has been increasing,and many potential genes causing MCD have been successively identified.However,the high genetic heterogeneity of MCD makes it challenging to understand the molecular pathogenesis of MCD and to identify effective targeted drugs.Thus,in this review,we outline important events of cortical development.Then we illustrate the progress of molecular genetic studies about MCD focusing on the PI3K/PTEN/AKT/mTOR pathway.Finally,we briefly discuss the diagnostic methods,disease models,and therapeutic strategies for MCD.The information will facilitate further research on MCD.Understanding the role of the PI3K/PTEN/AKT/mTOR pathway in MCD could lead to a novel strategy for treating MCD-related diseases.展开更多
The treatment of infants with established bronchopulmonary dysplasia （BPD） remains a common,frustrating and expensive problem in neonatology, pediatric PlUlmonology, pediatric critical care and general pediatrics.
文摘In order to identify family factors obviously relevant to aggression, and offer a theoretical foundation for the prevention of aggression, 4010 students from primary and secondary schools in 5 different areas in Hubei province were surveyed. The Child Behavior Checklist ＂ parents＂ form＂ （Chinese version） and the four scales of Family Environment Scale were used. A multiple logistic regression was used to identify risk factors of children＇s and adolescents＂ aggressive behavior. The results showed that maternal education, paternal occupation, family type, parental child-rearing attitude and patterns, students＂ interpersonal relationship were significantly associated with the childreffs and adolescents＂ aggression. The risk factors of aggression were parental child-rearing patterns, peer relationship, teacher-student relationship, and family conflicts.
基金This study was supported by the "973" Program of the Ministry of Science and Technology, China (2001CB510310).
文摘To understand the prevalence and rehabilitation status of autism and mental retardation in China. Methods Screening test and clinical assessment were conducted for the diagnosis of autism and mental retardation. The assessment included investigation of the histories of medical conditions and development of these two disorders, utilization and needs for the rehabilitation service, and related intellectual and behavioral appraisal. Results Among the 7345 children investigated, the prevalence of autism disorder was 1.10 cases per 1000 children aged 2-6 years （95% CI=0.34 to 2.54）, and the prevalence of mental retardation was 10.76 cases per 1000 children （95% CI=8.40 to 13.12）. All the children suffering from autistic disorder were intellectually disabled, whereas 31.0% of the non-autism mental retardates had other disabilities. The medical conditions prior to birth and perinatal period were important potential factors for autism. Half of the autistic children and 84% of the children with non-autism mental retardation had never received any rehabilitative service. Conclusions The prevalence of autistic disorder in children aged 2-6 years in Tianjin is rather high. It is urgent to improve the status of the autistic and intelligently disabled young children in China. In order to upgrade the level of early diagnostic and improve the intervention to autism and mental retardation, public awareness and training courses should be heightened.
基金supported by Health Department of Hubei Province(No.JX1B161).
文摘Objective To explore the endocfinal factors which influence the aggressive behavior of adolescents. Methods The levels of cortisol （CORT）, testosterone （T）, prolactin （PRL）, and growth hormone （GH） in saliva from 20 aggressive students and 20 non-aggressive control students were measured by radioimmunoassay （RIA）. The students were matched for their gender, age, grade, stage of pubertal development, and economic status of their families. Results The salivary T levels were 22.20±14.50 pg/mL and 19.54±12.52 pg/mL in aggressive male and female students, 13.20±6.85 pg/mL and 5.24±3.03 pg/mL in non-aggressive male and female students （P〈0.05）. The male aggressive students had a lower level of CORT in saliva than non-aggressive male students （P〈0.05）. There were no significant differences in the salivary levels of PRL or GH between the aggressive and non-aggressive groups. Correlation analysis revealed a negative relationship in male students between the salivary CORT levels and the aggression factor scores of the child behavior checklist （CBCL）. In addition, the data also showed a positive relationship between the salivary T levels and the aggression factor scores of CBCL in female students. Multiple linear regression analysis showed that the salivary CORT level was an independent predictive factor for aggressive behaviors in adolescent boys. The higher the CORT level, the less aggressive the boys were. Conclusion CORT and T levels may play a certain role in adolescent aggressive behaviors.
基金supported by the National Natural Science Foundation of China [81502823]Outstanding Young Talent Key program of College and University in Anhui province [gxyq ZD2017063]University Natural Science Foundation of Anhui province [KJ2019A0298]
文摘Objective The aim of this study was to analyze the mediating effect of body dissatisfaction in correlation between obesity and dietary behavior changes for weight loss(DBCWL).Methods A total of 680 primary and middle school students were included in this study. Their body height, weight, and waistline were effectively measured, and they were also evaluated to assess their body dissatisfaction, perception of dietary behaviors, and DBCWL. The correlation among these factors was analyzed using mediating effect models.Results The prevalence of overweight/obesity and abdominal obesity was significantly higher in males than in females(P < 0.05). Overweight/obesity, abdominal obesity, and body dissatisfaction significantly increased the risk for DBCWL(OR = 2.57, 2.77, and 1.95, respectively). Overweight/obesity and abdominal obesity significantly increased the risk for body dissatisfaction(OR = 6.00 and 4.70,respectively). Significant mediating effects of body dissatisfaction were observed in correlation between overweight/obesity and DBCWL and between abdominal obesity and DBCWL(OR = 2.20 and 1.92,respectively;P < 0.05), and the proportions of mediating effects among the total effects were 48.89% and 46.60%, respectively.Conclusion Body dissatisfaction might play an important mediating effect in association between DBCWL and obesity, which indicates that guiding children to correctly recognize their body might be more conducive than promoting obese children toward weight loss through dietary behavior changes.
基金supported by Liaoning Nature Science Foundation of China(project number 2015020466)the National Natural Science Foundation of China(project number 81072311)
文摘Rats were exposed to1 or 10 μg/mL bisphenol A （BPA） in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day （PND） 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin （ADP） levels in both female and male offspring rats. Liver adipose triglyceride lipase （Atgl） mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.
文摘Inhibitory ability of children with developmental dyscalculia（DD） was investigated to explore the cognitive mechanism underlying DD.According to the definition of developmental dyscalculia,19 children with DD-only and 10 children with DD＆RD（DD combined with reading disability） were selected step by step,children in two control groups were matched with children in case groups by gender and age,and the match ratio was 1：1.Psychological testing software named DMDX was used to measure inhibitory ability of the subjects.The differences of reaction time in number Stroop tasks and differences of accuracy in incongruent condition of color-word Stroop tasks and object inhibition tasks between DD-only children and their controls reached significant levels（P〈0.05）,and the differences of reaction time in number Stroop tasks between dyscalculic and normal children did not disappear after controlling the non-executive components.The difference of accuracy in color-word incongruent tasks between children with DD＆RD and normal children reached significant levels（P〈0.05）.Children with DD-only confronted with general inhibitory deficits,while children with DD＆RD confronted with word inhibitory deficits only.
基金This project is supported by a grant from the National Natural Sciences Foundation (No. 30100207)a grant from the Top Ten Scientific Research Programs of Shandong Province (No. 2004GG3202003)
文摘To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to pass the universal newborn hearing screening （UNHS） were referred to Jinan Newborn Hearing Screening and Rehabilitation Center from 7 newborn hearing screening centers in seven cities of Shandong province. One-to-one pair-matched case-control method was employed for statistical analysis of the basic features of definitely identified cases. High-risk factors relating to the bilateral hearing loss were evaluated by univariate and multivariate Logistic regression analysis. Our results revealed that 721 transferred newborns who didn＇t pass the heating screening received audiological and medical evaluation and 367 were confirmed to have hearing loss. Of them, 177 neonates with hearing loss who met the matching requirements were included in the study as subjects. Univariate analysis showed that high-risk factors related to hearing loss incuded age of father, education backgrounds of parents, parity, birth weight, gestational weeks, craniofacial deformity, history of receiving treatment in neonatal intensive care unit （NICU）, neonatal disease, family history of otopathy and family history of congenital hearing loss. Multivariate Logistic regression analysis revealed that 4 independent risk factors were related to bilateral hearing loss, including parity （OR=16.285, 95% CI 3.379--78,481）, neonatal disease （OR=34;968, 95% CI 2.720 449.534）, family history of congenital hearing loss （OR=69.488, 95% CI 4.417--1093.300） and birth weight （OR=0.241, 95% CI 0.090--0.648）. It is concluded that parity, neonatal disease and family history of heating loss are the promoting factors of bilateral hearing loss in neonates and appropriate intervention measures should be taken to deal with the risk factors.
文摘What is already known about this topic?The prevalence of mental health disorders among children and youth in China stands at 17.5%,a figure that has been gradually escalating over recent years.This surge has led to substantial psychological distress and financial strain for both families and the wider society.What is added by this report?This study boasts an expansive geographical scope by covering the Jiangsu Province extensively and utilizing a substantial sample size.An investigation was conducted on the prevalence and risk factors,which included family type and health behaviors,of depressive,anxiety,and stress symptoms.What are the implications for public health practice?The mental health status of children and adolescents should be of great concern to the government.Therefore,it is important that public health measures are implemented to mitigate the development of depressive symptoms.These measures may include regular screening procedures and the implementation of proven interventions.
文摘To assess the potential therapeutic effect of propofol in the treatment of endotoxemia, 76 rats were randomly assigned to 5 groups: control group(A), endotoxemic group(B), pre-treatment group(C), simultaneous treatment group(D) and post-treatment group(E) Five h after endotoxin injection, PO 2, pH, MAP, plasma concentrations of Nitrite/nitrate (NO - 2/NO - 3) and mortality rates were assessed in each group After the rats were sacrificed, lung tissue was sampled to measure myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-α contents It was found that endotoxin injection produced progressive hypotension, metabolic acidosis, and a large increase in the plasma NO - 2/NO - 3concentrations and increased mortality rates in 5h Endotoxin injection significantly increased MPO activity and TNF-α contents in lung tissue ( P <0 01 or P <0 05) These changes response to endotoxin were significantly attenuated in the groups B, C and D But these beneficial effects were blunted in the group E The results suggest that propofol administration may offer advantages in endotoxemia
文摘studies have suggested that non-optimal temperatures may increase the risk of injury,epidemiological studies focusing on the association between temperature and non-fatal injury among children and adolescents are limited.Therefore,we investigated the short-term effect of ambient temperature on non-fatal falls and road traffic injuries(RTIs)among students across Jiangsu Province,China.Meteorological data and records of non-fatal outdoor injuries due to falls and RTIs among students aged 6–17 were collected during 2018–2020.We performed a time-stratified case-crossover analysis with a distributed lag nonlinear model to examine the effect of ambient temperature on the risk of injury.Individual meteorological exposure was estimated based on the address of the selected school.We also performed stratified analyses by sex,age,and area.A total of 57322 and 5455 cases of falls and RTIs were collected,respectively.We observed inverted U-shaped curves for temperatureinjury associations,with maximum risk temperatures at 18℃(48th of daily mean temperature distribution)for falls and 22℃(67th of daily mean temperature distribution)for RTIs.The corresponding odds ratios(95%confidence intervals)were 2.193(2.011,2.391)and 3.038(1.988,4.644)for falls and RTIs,respectively.Notably,there was a significant age-dependent trend in which the temperature effect on falls was greater in older students(P-trend<0.05).This study suggests a ignificant association between ambient temperature and students’outdoor falls and RTIs.Our findings may help advance tailored strategies to reduce the incidence of outdoor falls and RTIs in children and adolescents.
基金Support from the National Social Science Foundation of China(Grant no.23CGL072)the Ministry of Science and Technology(Grant no.G2023141005L)+1 种基金the Ministry of Education(Grant no.1125000172)the Jiangsu Provincial Department of Science and Technology.
文摘What is already known about this topic?Interventions aimed at modifying lifestyle behaviors can effectively reduce the risk of depression among adolescents.These lifestyle behaviors tend to be interconnected;thus,changes to one behavior can often lead to changes in others,usually occurring simultaneously.What is added by this report?Adolescents from Jiangsu Province displayed distinct lifestyle patterns,with those engaging in multiple specific behaviors,such as excessive consumption of sugar-sweetened beverages and prolonged screen time,showing increased odds of depression.What are the implications for public health practice?Early implementation of anti-depression interventions in adolescents should be advocated and prioritized,particularly targeting multiple high-risk lifestyles.
基金funded by the National Institute on Ageing(R01 AG030153,RC2 AG036619,R03 AG043052).
文摘There has been lack of studies that investigate the causal impact of alcohol consumption on health and mortality in middle-aged and older populations in China.This cohort study aims to investigate whether alcohol use increases poor health and mortality risk in middle-aged and older Chinese population.The study is a cohort study design that was based on the China Health and Retired Longitudinal study(CHARLS).Measures of poor health and alcohol use are self-rated poor/very poor and alcohol use.Competing Cox proportional hazard regression model(CPHM)was used to model the data and the hazards ratio(HR)of poor health,mortality for current and former drinkers versus nondrinkers and current drinkers versus former drinkers was estimated using CPHM after adjusting for deign-effects and covariates.This study found significantly increased risk of all-cause mortality among current(adjusted HR=1.54 and P=0.0423)and former drinkers(Adjusted HR=1.52 and P=0.0096)compared to lifetime nondrinkers among middle-aged and senior Chinese people;significantly increased hazard of poor health among current drinkers(Adjusted HR=1.26 and P=0.0443)compared with lifetime nondrinkers.The hazards of all-cause mortality and self-rated poor health increased with the amount and frequency of alcohol drinking,and drinking years.This study found that either former or current drinkers self-rated having a poor health and had a significantly increased risk of all-cause mortality compared with nondrinkers.Heavy drinkers had poor health status and higher risk of mortality compared with those who drank light or moderate amount of alcohol in middle-aged and senior Chinese population.
文摘Childhood obesity has becoming an increasing concern in many countries including China [1-3].Located in the eastern China,Jiangsu Province is one of the developed regions in China and is also facing this problem.
基金the Tou-Yan Innovation Team Program of the Heilongjiang Province,China(No.2019-15).
文摘Malformations of cortical development(MCD)are a group of developmental disorders characterized by abnormal cortical structures caused by genetic or harmful environmental factors.Many kinds of MCD are caused by genetic variation.MCD is the common cause of intellectual disability and intractable epilepsy.With rapid advances in imaging and sequencing technologies,the diagnostic rate of MCD has been increasing,and many potential genes causing MCD have been successively identified.However,the high genetic heterogeneity of MCD makes it challenging to understand the molecular pathogenesis of MCD and to identify effective targeted drugs.Thus,in this review,we outline important events of cortical development.Then we illustrate the progress of molecular genetic studies about MCD focusing on the PI3K/PTEN/AKT/mTOR pathway.Finally,we briefly discuss the diagnostic methods,disease models,and therapeutic strategies for MCD.The information will facilitate further research on MCD.Understanding the role of the PI3K/PTEN/AKT/mTOR pathway in MCD could lead to a novel strategy for treating MCD-related diseases.
文摘The treatment of infants with established bronchopulmonary dysplasia （BPD） remains a common,frustrating and expensive problem in neonatology, pediatric PlUlmonology, pediatric critical care and general pediatrics.
