脂代谢是机体重要代谢之一,肝脏作为脂质合成、储存以及代谢的中心器官,二者相互影响。肿瘤细胞所处的局部环境称为肿瘤微环境,为适应肿瘤微环境而发生的代谢改变称为代谢重编。目前脂代谢与肝癌之间的相关性尚不完全清楚,肝癌脂代谢重...脂代谢是机体重要代谢之一,肝脏作为脂质合成、储存以及代谢的中心器官,二者相互影响。肿瘤细胞所处的局部环境称为肿瘤微环境,为适应肿瘤微环境而发生的代谢改变称为代谢重编。目前脂代谢与肝癌之间的相关性尚不完全清楚,肝癌脂代谢重编的具体过程亦尚未完全揭示。本文介绍了肝癌发生、发展各阶段脂代谢特点,总结了肝癌脂代谢重编过程的最新发现,旨在探究脂代谢在肝癌发生、发展以及预后中的作用,为肝癌防治提供新的思路与依据。Lipid metabolism is one of the important metabolic processes in the body, and the liver is the central organ for lipid synthesis, storage, and metabolism, with a mutual influence between them. The local environment in which the tumour cells are located is called the tumor microenvironment, and the metabolic changes that occur to adapt to the tumor microenvironment are called metabolic reprogramming. At present, the relationship between lipid metabolism and liver cancer is not completely clear, and the specific process of lipid metabolic reprogramming in liver cancer has not yet been fully elucidated. This review introduces the lipid metabolic characteristics of liver cancer at each stage of its occurrence and development, summarizes the latest findings on the lipid metabolic reprogramming process in liver cancer, and aims to explore the role of lipid metabolism in the occurrence, development, and prognosis of liver cancer, providing new ideas and evidence for the prevention and treatment of liver cancer.展开更多
文摘脂代谢是机体重要代谢之一,肝脏作为脂质合成、储存以及代谢的中心器官,二者相互影响。肿瘤细胞所处的局部环境称为肿瘤微环境,为适应肿瘤微环境而发生的代谢改变称为代谢重编。目前脂代谢与肝癌之间的相关性尚不完全清楚,肝癌脂代谢重编的具体过程亦尚未完全揭示。本文介绍了肝癌发生、发展各阶段脂代谢特点,总结了肝癌脂代谢重编过程的最新发现,旨在探究脂代谢在肝癌发生、发展以及预后中的作用,为肝癌防治提供新的思路与依据。Lipid metabolism is one of the important metabolic processes in the body, and the liver is the central organ for lipid synthesis, storage, and metabolism, with a mutual influence between them. The local environment in which the tumour cells are located is called the tumor microenvironment, and the metabolic changes that occur to adapt to the tumor microenvironment are called metabolic reprogramming. At present, the relationship between lipid metabolism and liver cancer is not completely clear, and the specific process of lipid metabolic reprogramming in liver cancer has not yet been fully elucidated. This review introduces the lipid metabolic characteristics of liver cancer at each stage of its occurrence and development, summarizes the latest findings on the lipid metabolic reprogramming process in liver cancer, and aims to explore the role of lipid metabolism in the occurrence, development, and prognosis of liver cancer, providing new ideas and evidence for the prevention and treatment of liver cancer.
