Background:The enduring and detrimental impact of childhood trauma on later health and well-being is now well established.However,research on the relationship between childhood trauma and depressive symptoms,along wit...Background:The enduring and detrimental impact of childhood trauma on later health and well-being is now well established.However,research on the relationship between childhood trauma and depressive symptoms,along with the potential risk and protective factors,is insufficient in the context of Chinese college student population.Methods:Data on childhood trauma,depressive symptoms,resilience,and subjective well-being were collected through surveys conducted with 367 Chinese university students.The data collected in this study were analyzed using SPSS 26.0 and PROCESS 3.5.Results:The results revealed that subjective well-being mediated the relationship between childhood trauma and depressive symptoms among college students,with direct and indirect effects accounting for 59.46%and 40.54%of the total effect,respectively.The pathway process between subjective well-being and depressive symptoms was moderated by resilience,whereby an increase in resilience levels corresponded to a gradual escalation in the predictive power of subjective well-being on depressive symptoms.Conclusion:The study indicates that childhood trauma significantly and positively predicts depressive symptoms among college students,and it can also directly predict depressive symptoms through the mediating effect of subjective well-being.Elevating levels of psychological resilience and subjective well-being among college students can mitigate depression and promote psychological well-being.From the perspective of positive psychology,the present study provides a new perspective for the prevention and intervention of depressive symptoms among college students.展开更多
BACKGROUND The use of antidepressant therapy alone has a limited efficacy in patients with childhood trauma-associated major depressive disorder(MDD).However,the effectiveness of antidepressant treatment combined with...BACKGROUND The use of antidepressant therapy alone has a limited efficacy in patients with childhood trauma-associated major depressive disorder(MDD).However,the effectiveness of antidepressant treatment combined with psychodrama in these patients is unclear.AIM To evaluate the effectiveness of antidepressant treatment combined with psychodrama.METHODS Patients with childhood trauma-associated MDD treated with antidepressants were randomly assigned to either the psychodrama intervention(observation group)or the general health education intervention(control group)and received combination treatment for 6 mo.The observation group received general health education given by the investigator together with the“semi-structured group intervention model”of Yi Shu psychodrama.A total of 46 patients were recruited,including 29 cases in the observation group and 17 cases in the control group.Symptoms of depression and anxiety as well as coping style and resting-state functional magnetic resonance imaging were assessed before and after the intervention.RESULTS Symptoms of depression and anxiety,measured by the Hamilton Depression Scale,Beck Depression Inventory,and Beck Anxiety Inventory,were reduced after the intervention in both groups of patients.The coping style of the observation group improved significantly in contrast to the control group,which did not.In addition,an interaction between treatment and time in the right superior parietal gyrus node was found.Furthermore,functional connectivity between the right superior parietal gyrus and left inferior frontal gyrus in the observation group increased after the intervention,while in the control group the connectivity decreased.CONCLUSION This study supports the use of combined treatment with antidepressants and psychodrama to improve the coping style of patients with childhood trauma-associated MDD.Functional connectivity between the superior parietal gyrus and inferior frontal gyrus was increased after this combined treatment.We speculate that psychodrama enhances the internal connectivity of the cognitive control network and corrects the negative attention bias of patients with childhood trauma-associated MDD.Elucidating the neurobiological features of patients with childhood trauma-associated MDD is important for the development of methods that can assist in early diagnosis and intervention.展开更多
Studies for prevalence and causal relationship established that addressing comorbidities of mental illnesses with medical disease will be another revolution in psychiatry. Increasing number of evidence shows that ther...Studies for prevalence and causal relationship established that addressing comorbidities of mental illnesses with medical disease will be another revolution in psychiatry. Increasing number of evidence shows that there is a bidirectional connection between mood disorders and some medical diseases. Glucocorticoid/insulin signal mechanisms and immunoenflammatory effector systems are junction points that show pathophysiology between bipolar disorder and general medical situations susceptible to stress. A subgroup of mood disorder patients are under risk of developing obesity and diabetes. Their habits and life styles, genetic predisposition and treatment options are parameters that define this subgroup. Medical disease in adults had a significant relationship to adverse life experiences in childhood. This illustrates that adverse experiences in childhood are related to adult disease by two basic etiologic mechanisms:(1) conventional risk factors that actually are compensatory behaviors, attempts at selfhelp through the use of agents and foods; and(2) the effects of chronic stress.展开更多
This review serves to analyze the relationship between childhood trauma and addiction;provide an overview of the science behind addiction;analyze issues with current addiction treatment methods and protocols;as well a...This review serves to analyze the relationship between childhood trauma and addiction;provide an overview of the science behind addiction;analyze issues with current addiction treatment methods and protocols;as well as to provide a list of proposed changes to modernize addiction treatment to a level of quality which will prove much more successful in the treatment of addicts.展开更多
Children from all walks of life are subjected to traumatic experiences.Having one traumatic experience,while unfortunate,generally does not have much impact on the child’s future,as one might expect.This review exami...Children from all walks of life are subjected to traumatic experiences.Having one traumatic experience,while unfortunate,generally does not have much impact on the child’s future,as one might expect.This review examines the long-term psychoneuroendocrinologocal implications of repeated or prolonged exposure to traumatic events during childhood,particularly during the formative years which include chronic illnesses,terminal illnesses,psychological disorders,neurological disorders,and more which has resulted in an average reduced life expectancy of 20-years.Proposed modifications for screening tools,prevention,and interventions are explained and introduced.In conclusion,this review proposes a modified and universal approach to screening,prevention,and treatment for those at high risk and those already afflicted by childhood trauma based on the latest in evidence-based research.展开更多
Background To investigate the prevalence,risk factors,and impacts of childhood trauma in Chinese patients with psychogenic non-epileptic seizures(PNES)compared to the healthy population.Methods Patients with PNES and ...Background To investigate the prevalence,risk factors,and impacts of childhood trauma in Chinese patients with psychogenic non-epileptic seizures(PNES)compared to the healthy population.Methods Patients with PNES and sex-and age-matched healthy controls were recruited.All the participants were interviewed to collect demographics,information of childhood environment,and clinical characteristics.Each participant completed the Childhood Trauma Questionnaire-Short Form(CTQ-SF),the Dissociative Experiences Scale(DES),and the Symptom Checklist-90(SCL-90).Factors associated with childhood trauma,psychiatric symptoms,and clinical features of PNES were analyzed.Results A total of 35 PNES patients and 34 controls were included in this study.Compared with the controls,the PNES patients reported a higher rate of childhood trauma and more severe psychiatric symptoms.In the PNES patients,early separation from parents was related to more types of childhood trauma and emotional neglect(EN);older age and rural residence during childhood were related to sexual abuse(SA).Moreover,childhood SA and trauma accumulation were correlated with the present psychiatric symptoms.Childhood trauma and rural residence were associated with dissociative symptoms.Separation from parents predicted an earlier PNES onset,whereas childhood SA predicted a later onset.More severe dissociative symptoms were associated with higher seizure frequency.Conclusions Childhood trauma is related to the development of PNES and the compromised mental health in PNES patients.This highlights the importance of child protection for preventing psychiatric disorders such as PNES.展开更多
Background:Aggression is a commonly hostile behavior linked to the hippocampal activity.Childhood trauma(CT)exposure has been associated with altered sensitization of the hypothalamic-pituitary-adrenal(HPA)axis and hi...Background:Aggression is a commonly hostile behavior linked to the hippocampal activity.Childhood trauma(CT)exposure has been associated with altered sensitization of the hypothalamic-pituitary-adrenal(HPA)axis and hippocampal volumewhich could increase violent aggressive behaviors.Additionally,Catechol-O-methyltransferase(COMT),the major dopamine metabolism enzyme,is impli-cated in stress responsivity,including aggression.Hence,CT exposure may affect aggression through the effect on the hippocampal function,which might also be modulated by the COMT variations.Objectives:This study examined whether both CT and haplotypes of COMT moderate hippocampal function and thus affect human aggressive behavior.Methods:We obtained bilateral hippocampal functional connectivity maps using resting state functional magnetic resonance imag-ing(MRI)data.COMT haplotype estimation was performed using Haploview 4.2 and PHASE 2.1.Then we constructed a moderated mediation model to study the effect of the CTQ×COMT on aggressive behavior.Results:Three major haplotypes were generated from thirteen single nucleotide polymorphisms(SNPs)within the COMT gene and formed three haplotypes corresponding to high,medium,and low enzymatic activity of COMT.The results showed interactive re-lationships between the Childhood Trauma Questionnaire(CTQ)and COMT with respect to the functional connectivity(FC)of the bilateral hippocampus(HIP)-orbital frontal cortex(OFC).Specifically,CT experience predicted lower negative HIP-OFC coupling in the APS and HPS haplotypes corresponding to the medium and high enzymatic activity of COMT,but greater FC in the LPS haplotypes corresponding to the low enzymatic activity.We also observed a conditional mediation effect of the right HIP-OFC coupling in the link between COMT and aggressive behavior that was moderated by CT experience.Conclusions:These results suggest that CT and COMT have a combined effect on aggressive behavior through hippocampal function.This mediation analysis sheds light on the influence of childhood experience on aggressive behavior in different genetic backgrounds.展开更多
BACKGROUND Alexithymia is defined as difficulties in identifying,expressing,and understanding emotions.An unapproving environment during childhood is defined as the child not receiving emotional approval from their pa...BACKGROUND Alexithymia is defined as difficulties in identifying,expressing,and understanding emotions.An unapproving environment during childhood is defined as the child not receiving emotional approval from their parents,being punished,or having their emotions devalued.The formation of self-esteem is shaped by the influence of parental behavior during childhood.The commu-nication that the child establishes with their parents contributes to their increased self-esteem and sense of importance.The absence of this may play a role in developmental psychopathology.AIM To examine the mediating role of self-esteem in the relationship between a disapproving environment in childhood and alexithymia.METHODS The research in the relational screening model was conducted with 404 participants.Demographic Information Form,Disapproving Environment Scale in Childhood,Toronto Alexithymia Scale,and Rosenberg Self-Esteem Scale were used as data collection tools.Hayes’bootstrapping technique was used in the analysis of the data obtained from the research.RESULTS As a result of the analyses,parental disapproval positively predicted the level of alexithymia(rmother=0.51,rfather=0.52,P<0.05)and negatively predicted selfesteem(rmother=-0.75,rfather=-0.67,P<0.05).Additionally,self-esteem negatively predicted alexithymia(r=-0.58,P<0.05).It was observed that self-esteem had a partial mediating effect on the relationship between parental disapproval and alexithymia.Family types were analyzed separately as chaotic,approving,perfect,and typical.Of these,the chaotic family type positively predicted alexithymia(r=0.33,P<0.05)and negatively predicted self-esteem(r=-0.60,P<0.05).The approving family type negatively predicted alexithymia(r=-0.43,P<0.05)and positively predicted self-esteem(r=0.61,P<0.05).The perfect family type negatively predicted alexithymia(r=-0.27,P<0.05)and positively predicted self-esteem(r=-0.45,P<0.05).CONCLUSION The type of family in which the child grows up in and parental disapproval during childhood affected the child’s self-esteem and caused alexithymic personality traits.展开更多
基金Yunnan Provincial Department of Education Science Research Fund(2024J0412).
文摘Background:The enduring and detrimental impact of childhood trauma on later health and well-being is now well established.However,research on the relationship between childhood trauma and depressive symptoms,along with the potential risk and protective factors,is insufficient in the context of Chinese college student population.Methods:Data on childhood trauma,depressive symptoms,resilience,and subjective well-being were collected through surveys conducted with 367 Chinese university students.The data collected in this study were analyzed using SPSS 26.0 and PROCESS 3.5.Results:The results revealed that subjective well-being mediated the relationship between childhood trauma and depressive symptoms among college students,with direct and indirect effects accounting for 59.46%and 40.54%of the total effect,respectively.The pathway process between subjective well-being and depressive symptoms was moderated by resilience,whereby an increase in resilience levels corresponded to a gradual escalation in the predictive power of subjective well-being on depressive symptoms.Conclusion:The study indicates that childhood trauma significantly and positively predicts depressive symptoms among college students,and it can also directly predict depressive symptoms through the mediating effect of subjective well-being.Elevating levels of psychological resilience and subjective well-being among college students can mitigate depression and promote psychological well-being.From the perspective of positive psychology,the present study provides a new perspective for the prevention and intervention of depressive symptoms among college students.
文摘BACKGROUND The use of antidepressant therapy alone has a limited efficacy in patients with childhood trauma-associated major depressive disorder(MDD).However,the effectiveness of antidepressant treatment combined with psychodrama in these patients is unclear.AIM To evaluate the effectiveness of antidepressant treatment combined with psychodrama.METHODS Patients with childhood trauma-associated MDD treated with antidepressants were randomly assigned to either the psychodrama intervention(observation group)or the general health education intervention(control group)and received combination treatment for 6 mo.The observation group received general health education given by the investigator together with the“semi-structured group intervention model”of Yi Shu psychodrama.A total of 46 patients were recruited,including 29 cases in the observation group and 17 cases in the control group.Symptoms of depression and anxiety as well as coping style and resting-state functional magnetic resonance imaging were assessed before and after the intervention.RESULTS Symptoms of depression and anxiety,measured by the Hamilton Depression Scale,Beck Depression Inventory,and Beck Anxiety Inventory,were reduced after the intervention in both groups of patients.The coping style of the observation group improved significantly in contrast to the control group,which did not.In addition,an interaction between treatment and time in the right superior parietal gyrus node was found.Furthermore,functional connectivity between the right superior parietal gyrus and left inferior frontal gyrus in the observation group increased after the intervention,while in the control group the connectivity decreased.CONCLUSION This study supports the use of combined treatment with antidepressants and psychodrama to improve the coping style of patients with childhood trauma-associated MDD.Functional connectivity between the superior parietal gyrus and inferior frontal gyrus was increased after this combined treatment.We speculate that psychodrama enhances the internal connectivity of the cognitive control network and corrects the negative attention bias of patients with childhood trauma-associated MDD.Elucidating the neurobiological features of patients with childhood trauma-associated MDD is important for the development of methods that can assist in early diagnosis and intervention.
文摘Studies for prevalence and causal relationship established that addressing comorbidities of mental illnesses with medical disease will be another revolution in psychiatry. Increasing number of evidence shows that there is a bidirectional connection between mood disorders and some medical diseases. Glucocorticoid/insulin signal mechanisms and immunoenflammatory effector systems are junction points that show pathophysiology between bipolar disorder and general medical situations susceptible to stress. A subgroup of mood disorder patients are under risk of developing obesity and diabetes. Their habits and life styles, genetic predisposition and treatment options are parameters that define this subgroup. Medical disease in adults had a significant relationship to adverse life experiences in childhood. This illustrates that adverse experiences in childhood are related to adult disease by two basic etiologic mechanisms:(1) conventional risk factors that actually are compensatory behaviors, attempts at selfhelp through the use of agents and foods; and(2) the effects of chronic stress.
文摘This review serves to analyze the relationship between childhood trauma and addiction;provide an overview of the science behind addiction;analyze issues with current addiction treatment methods and protocols;as well as to provide a list of proposed changes to modernize addiction treatment to a level of quality which will prove much more successful in the treatment of addicts.
文摘Children from all walks of life are subjected to traumatic experiences.Having one traumatic experience,while unfortunate,generally does not have much impact on the child’s future,as one might expect.This review examines the long-term psychoneuroendocrinologocal implications of repeated or prolonged exposure to traumatic events during childhood,particularly during the formative years which include chronic illnesses,terminal illnesses,psychological disorders,neurological disorders,and more which has resulted in an average reduced life expectancy of 20-years.Proposed modifications for screening tools,prevention,and interventions are explained and introduced.In conclusion,this review proposes a modified and universal approach to screening,prevention,and treatment for those at high risk and those already afflicted by childhood trauma based on the latest in evidence-based research.
基金supported by the National Natural Science Foundation of China(82101523,82171443 and 81771402)Sichuan International Science and Technology Innovation Cooperation/Hong Kong,Macao and Taiwan Science and Technology Innovation Cooperation Project(2021YFH0136)the 1.3.5 project for disciplines of excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University(2019HXFH047).
文摘Background To investigate the prevalence,risk factors,and impacts of childhood trauma in Chinese patients with psychogenic non-epileptic seizures(PNES)compared to the healthy population.Methods Patients with PNES and sex-and age-matched healthy controls were recruited.All the participants were interviewed to collect demographics,information of childhood environment,and clinical characteristics.Each participant completed the Childhood Trauma Questionnaire-Short Form(CTQ-SF),the Dissociative Experiences Scale(DES),and the Symptom Checklist-90(SCL-90).Factors associated with childhood trauma,psychiatric symptoms,and clinical features of PNES were analyzed.Results A total of 35 PNES patients and 34 controls were included in this study.Compared with the controls,the PNES patients reported a higher rate of childhood trauma and more severe psychiatric symptoms.In the PNES patients,early separation from parents was related to more types of childhood trauma and emotional neglect(EN);older age and rural residence during childhood were related to sexual abuse(SA).Moreover,childhood SA and trauma accumulation were correlated with the present psychiatric symptoms.Childhood trauma and rural residence were associated with dissociative symptoms.Separation from parents predicted an earlier PNES onset,whereas childhood SA predicted a later onset.More severe dissociative symptoms were associated with higher seizure frequency.Conclusions Childhood trauma is related to the development of PNES and the compromised mental health in PNES patients.This highlights the importance of child protection for preventing psychiatric disorders such as PNES.
基金supported by the Natural Science Foundation of China (Grant Nos 31600920,91232718,and 91132301)the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No.XDB02030300)+1 种基金the Natural Science Foundation of Guangdong Province (No.2019A1515012134)the Shenzhen Basic Research Project (Grant No.20220526002851001,JCYJ2017081802123707 and 20200807225058001)。
文摘Background:Aggression is a commonly hostile behavior linked to the hippocampal activity.Childhood trauma(CT)exposure has been associated with altered sensitization of the hypothalamic-pituitary-adrenal(HPA)axis and hippocampal volumewhich could increase violent aggressive behaviors.Additionally,Catechol-O-methyltransferase(COMT),the major dopamine metabolism enzyme,is impli-cated in stress responsivity,including aggression.Hence,CT exposure may affect aggression through the effect on the hippocampal function,which might also be modulated by the COMT variations.Objectives:This study examined whether both CT and haplotypes of COMT moderate hippocampal function and thus affect human aggressive behavior.Methods:We obtained bilateral hippocampal functional connectivity maps using resting state functional magnetic resonance imag-ing(MRI)data.COMT haplotype estimation was performed using Haploview 4.2 and PHASE 2.1.Then we constructed a moderated mediation model to study the effect of the CTQ×COMT on aggressive behavior.Results:Three major haplotypes were generated from thirteen single nucleotide polymorphisms(SNPs)within the COMT gene and formed three haplotypes corresponding to high,medium,and low enzymatic activity of COMT.The results showed interactive re-lationships between the Childhood Trauma Questionnaire(CTQ)and COMT with respect to the functional connectivity(FC)of the bilateral hippocampus(HIP)-orbital frontal cortex(OFC).Specifically,CT experience predicted lower negative HIP-OFC coupling in the APS and HPS haplotypes corresponding to the medium and high enzymatic activity of COMT,but greater FC in the LPS haplotypes corresponding to the low enzymatic activity.We also observed a conditional mediation effect of the right HIP-OFC coupling in the link between COMT and aggressive behavior that was moderated by CT experience.Conclusions:These results suggest that CT and COMT have a combined effect on aggressive behavior through hippocampal function.This mediation analysis sheds light on the influence of childhood experience on aggressive behavior in different genetic backgrounds.
文摘BACKGROUND Alexithymia is defined as difficulties in identifying,expressing,and understanding emotions.An unapproving environment during childhood is defined as the child not receiving emotional approval from their parents,being punished,or having their emotions devalued.The formation of self-esteem is shaped by the influence of parental behavior during childhood.The commu-nication that the child establishes with their parents contributes to their increased self-esteem and sense of importance.The absence of this may play a role in developmental psychopathology.AIM To examine the mediating role of self-esteem in the relationship between a disapproving environment in childhood and alexithymia.METHODS The research in the relational screening model was conducted with 404 participants.Demographic Information Form,Disapproving Environment Scale in Childhood,Toronto Alexithymia Scale,and Rosenberg Self-Esteem Scale were used as data collection tools.Hayes’bootstrapping technique was used in the analysis of the data obtained from the research.RESULTS As a result of the analyses,parental disapproval positively predicted the level of alexithymia(rmother=0.51,rfather=0.52,P<0.05)and negatively predicted selfesteem(rmother=-0.75,rfather=-0.67,P<0.05).Additionally,self-esteem negatively predicted alexithymia(r=-0.58,P<0.05).It was observed that self-esteem had a partial mediating effect on the relationship between parental disapproval and alexithymia.Family types were analyzed separately as chaotic,approving,perfect,and typical.Of these,the chaotic family type positively predicted alexithymia(r=0.33,P<0.05)and negatively predicted self-esteem(r=-0.60,P<0.05).The approving family type negatively predicted alexithymia(r=-0.43,P<0.05)and positively predicted self-esteem(r=0.61,P<0.05).The perfect family type negatively predicted alexithymia(r=-0.27,P<0.05)and positively predicted self-esteem(r=-0.45,P<0.05).CONCLUSION The type of family in which the child grows up in and parental disapproval during childhood affected the child’s self-esteem and caused alexithymic personality traits.
