In this manuscript we comment on the article by Yang et al published recently,focusing on how hepatic angiopoietin-2(Ang-2)transcription promote the pro-gression of hepatocellular carcinoma(HCC).HCC is one of the most...In this manuscript we comment on the article by Yang et al published recently,focusing on how hepatic angiopoietin-2(Ang-2)transcription promote the pro-gression of hepatocellular carcinoma(HCC).HCC is one of the most common and lethal malignancies worldwide,especially in regions with high hepatitis B virus infection rates.Ang-2 is a key mediator of angiogenesis and plays a significant role in the progression of chronic liver diseases towards HCC,particularly in the hypoxic microenvironment.This paper reviews the dynamic expression of Ang-2 in hepatocarcinogenesis and its regulation by hypoxia-inducible factor-1α.Fur-thermore,we discuss Ang-2’s potential as an early monitoring biomarker for me-tastasis,and the therapeutic prospects of silencing hypoxia-inducible factor-1αto downregulate Ang-2 and suppress epithelial-mesenchymal transition in HCC treatment.展开更多
Background Even though adrenocorticotropic hormone(ACTH)demonstrated powerful efficacy in the initially successful treatment of infantile spasms(IS),nearly half of patients have experienced a relapse.We sought to inve...Background Even though adrenocorticotropic hormone(ACTH)demonstrated powerful efficacy in the initially successful treatment of infantile spasms(IS),nearly half of patients have experienced a relapse.We sought to investigate whether features of electroencephalogram(EEG)predict relapse in those IS patients without structural brain abnormalities.Methods We retrospectively reviewed data from children with IS who achieved initial response after ACTH treatment,along with EEG recorded within the last two days of treatment.The recurrence of epileptic spasms following treatment was tracked for 12 months.Subjects were categorized as either non-relapse or relapse groups.General clinical and EEG recordings were collected,burden of amplitudes and epileptiform discharges(BASED)score and multiscale entropy(MSE)were carefully explored for cross-group comparisons.Results Forty-one patients were enrolled in the study,of which 26(63.4%)experienced a relapse.The BASED score was significantly higher in the relapse group.MSE in the non-relapse group was significantly lower than the relapse group in theγband but higher in the lower frequency range(δ,θ,α).Sensitivity and specificity were 85.71%and 92.31%,respectively,when combining MSE in theδ/γfrequency of the occipital region,plus BASED score were used to distinguish relapse from non-relapse groups.Conclusions BASED score and MSE of EEG after ACTH treatment could be used to predict relapse for IS patients without brain structural abnormalities.Patients with BASED score≥3,MSE increased in higher frequency,and decreased in lower frequency had a high risk of relapse.展开更多
基金Supported by the Basic and Clinical Integration Project of Xi’an Jiaotong University,No.YXJLRH2022067.
文摘In this manuscript we comment on the article by Yang et al published recently,focusing on how hepatic angiopoietin-2(Ang-2)transcription promote the pro-gression of hepatocellular carcinoma(HCC).HCC is one of the most common and lethal malignancies worldwide,especially in regions with high hepatitis B virus infection rates.Ang-2 is a key mediator of angiogenesis and plays a significant role in the progression of chronic liver diseases towards HCC,particularly in the hypoxic microenvironment.This paper reviews the dynamic expression of Ang-2 in hepatocarcinogenesis and its regulation by hypoxia-inducible factor-1α.Fur-thermore,we discuss Ang-2’s potential as an early monitoring biomarker for me-tastasis,and the therapeutic prospects of silencing hypoxia-inducible factor-1αto downregulate Ang-2 and suppress epithelial-mesenchymal transition in HCC treatment.
基金This research was partially supported by National Natural Science Foundation of China(Nos.62171028,62001026)the Natural Science Foundation of Beijing,China(No.7222187)+2 种基金the Medical Big Data and Artificial Intelligence Research and Development Project of the Chinese PLA General Hospital(No.2019MBD-004)the Epilepsy Research Fund of China Association Against Epilepsy(No.CU-B-2021-11)the Nutrition and Care of Maternal&Child Research Fund Project of Guangzhou Biostime Institute of Nutrition&Care(No.2021BINCMCF030).
文摘Background Even though adrenocorticotropic hormone(ACTH)demonstrated powerful efficacy in the initially successful treatment of infantile spasms(IS),nearly half of patients have experienced a relapse.We sought to investigate whether features of electroencephalogram(EEG)predict relapse in those IS patients without structural brain abnormalities.Methods We retrospectively reviewed data from children with IS who achieved initial response after ACTH treatment,along with EEG recorded within the last two days of treatment.The recurrence of epileptic spasms following treatment was tracked for 12 months.Subjects were categorized as either non-relapse or relapse groups.General clinical and EEG recordings were collected,burden of amplitudes and epileptiform discharges(BASED)score and multiscale entropy(MSE)were carefully explored for cross-group comparisons.Results Forty-one patients were enrolled in the study,of which 26(63.4%)experienced a relapse.The BASED score was significantly higher in the relapse group.MSE in the non-relapse group was significantly lower than the relapse group in theγband but higher in the lower frequency range(δ,θ,α).Sensitivity and specificity were 85.71%and 92.31%,respectively,when combining MSE in theδ/γfrequency of the occipital region,plus BASED score were used to distinguish relapse from non-relapse groups.Conclusions BASED score and MSE of EEG after ACTH treatment could be used to predict relapse for IS patients without brain structural abnormalities.Patients with BASED score≥3,MSE increased in higher frequency,and decreased in lower frequency had a high risk of relapse.
