目的分析阿司匹林、氯吡格雷联合阿加曲班治疗急性脑梗死的临床效果及对神经功能缺损评分的影响。方法选取徐州利国医院神经内科2023年1月—2024年1月收治的70例急性脑梗死患者(发病时间48 h之内)作为研究对象。按照随机对照试验法分为...目的分析阿司匹林、氯吡格雷联合阿加曲班治疗急性脑梗死的临床效果及对神经功能缺损评分的影响。方法选取徐州利国医院神经内科2023年1月—2024年1月收治的70例急性脑梗死患者(发病时间48 h之内)作为研究对象。按照随机对照试验法分为观察组与对照组,各35例。观察组在口服阿司匹林及氯吡格雷双联抗血小板聚集的基础上再予阿加曲班抗凝治疗,对照组仅予双联抗血小板聚集治疗。比较2组治疗1、2周后的临床疗效、神经功能缺损评分及安全性。结果治疗1、2周后,观察组美国国立卫生研究院脑卒中量表(national institute of health stroke scale,NIHSS)评分分别为(2.21±0.28)分、(2.18±0.43)分,均低于对照组的(4.53±0.65)分、(3.86±0.33)分;观察组改良Rankin量表(modified Rankin scale,mRS)评分分别为(2.28±0.73)分、(0.98±0.53)分,均低于对照组的(2.91±0.64)分、(1.62±0.87)分,差异有统计学意义(P<0.001)。治疗1、2周后,2组临床疗效比较,差异无统计学意义(P>0.05)。2组用药观察期间未见不良反应情况发生。结论对发病在48 h内的急性脑梗死患者应用阿司匹林、氯吡格雷联合阿加曲班能够改善患者神经功能缺损症状,且安全有效。展开更多
The effects of some commonly used penetration enhancers such as laurocapram (AZ), oleic acid (OA), poloxamer (POL) and propylene glycol (PG) on the in vitro transdermal iontophoretic delivery of insulin through fu...The effects of some commonly used penetration enhancers such as laurocapram (AZ), oleic acid (OA), poloxamer (POL) and propylene glycol (PG) on the in vitro transdermal iontophoretic delivery of insulin through full-thickness mouse skin were investigated. The results showed that AZ had a synergistic effect on iontophoretic ability to enhance skin permeation of insulin, and PG could further increase this effect. 5% AZ / PG increased the iontophoretic steady state flux of insulin by a factor of 2.75 compared to that treated with iontophoresis alone. OA did not further enhance iontophoretic effect to increase skin permeation of insulin. The combination of iontophoresis and some enhancer provided a novel idea and possibility for transdermal delivery of insulin.展开更多
Insulin-loaded poly(lactide-co-glycolide) nanoparticles (INS-PLGA-NPs) were prepared by a double emulsion method (w/o/w), using ethyl acetate as organic solvent and poloxamer188 as emulsifier. Experimental parameter...Insulin-loaded poly(lactide-co-glycolide) nanoparticles (INS-PLGA-NPs) were prepared by a double emulsion method (w/o/w), using ethyl acetate as organic solvent and poloxamer188 as emulsifier. Experimental parameters such as the emulsifier and PLGA concentrations, the pH and concentration of the insulin solution, the solvent evaporation method and PVA in the internal phase were investigated for the encapsulation efficiency. The results indicated that higher emulsifier concentration, relatively less amount of PLGA and lower insulin concentration would increase the entrapment of insulin. Furthermore, pH of insulin solution approaching to pI (5.3), adding some PVA to the internal phase and a shorter evaporation time helped to enhance the incorporation efficiency of insulin. Optimized preparation parameters led to nanoparticles with well-defined characteristics such as an average size around 149.6 nm, a polydispersity lower than 0.1 and high encapsulation efficiency up to 42.8%.展开更多
文摘目的分析阿司匹林、氯吡格雷联合阿加曲班治疗急性脑梗死的临床效果及对神经功能缺损评分的影响。方法选取徐州利国医院神经内科2023年1月—2024年1月收治的70例急性脑梗死患者(发病时间48 h之内)作为研究对象。按照随机对照试验法分为观察组与对照组,各35例。观察组在口服阿司匹林及氯吡格雷双联抗血小板聚集的基础上再予阿加曲班抗凝治疗,对照组仅予双联抗血小板聚集治疗。比较2组治疗1、2周后的临床疗效、神经功能缺损评分及安全性。结果治疗1、2周后,观察组美国国立卫生研究院脑卒中量表(national institute of health stroke scale,NIHSS)评分分别为(2.21±0.28)分、(2.18±0.43)分,均低于对照组的(4.53±0.65)分、(3.86±0.33)分;观察组改良Rankin量表(modified Rankin scale,mRS)评分分别为(2.28±0.73)分、(0.98±0.53)分,均低于对照组的(2.91±0.64)分、(1.62±0.87)分,差异有统计学意义(P<0.001)。治疗1、2周后,2组临床疗效比较,差异无统计学意义(P>0.05)。2组用药观察期间未见不良反应情况发生。结论对发病在48 h内的急性脑梗死患者应用阿司匹林、氯吡格雷联合阿加曲班能够改善患者神经功能缺损症状,且安全有效。
文摘The effects of some commonly used penetration enhancers such as laurocapram (AZ), oleic acid (OA), poloxamer (POL) and propylene glycol (PG) on the in vitro transdermal iontophoretic delivery of insulin through full-thickness mouse skin were investigated. The results showed that AZ had a synergistic effect on iontophoretic ability to enhance skin permeation of insulin, and PG could further increase this effect. 5% AZ / PG increased the iontophoretic steady state flux of insulin by a factor of 2.75 compared to that treated with iontophoresis alone. OA did not further enhance iontophoretic effect to increase skin permeation of insulin. The combination of iontophoresis and some enhancer provided a novel idea and possibility for transdermal delivery of insulin.
文摘Insulin-loaded poly(lactide-co-glycolide) nanoparticles (INS-PLGA-NPs) were prepared by a double emulsion method (w/o/w), using ethyl acetate as organic solvent and poloxamer188 as emulsifier. Experimental parameters such as the emulsifier and PLGA concentrations, the pH and concentration of the insulin solution, the solvent evaporation method and PVA in the internal phase were investigated for the encapsulation efficiency. The results indicated that higher emulsifier concentration, relatively less amount of PLGA and lower insulin concentration would increase the entrapment of insulin. Furthermore, pH of insulin solution approaching to pI (5.3), adding some PVA to the internal phase and a shorter evaporation time helped to enhance the incorporation efficiency of insulin. Optimized preparation parameters led to nanoparticles with well-defined characteristics such as an average size around 149.6 nm, a polydispersity lower than 0.1 and high encapsulation efficiency up to 42.8%.
