摘要
绘制了吡喹酮在丙二醇－乙醇－水系统中的相图，通过均匀设计确定了１％吡喹酮凝胶剂中各溶媒所占的最佳比例为：４０％（ｗ／ｗ）丙二醇，４５％（ｗ／ｗ）乙醇，５％（ｗ／ｗ）水。以卡波普９４０为基质制备了吡喹酮凝胶剂，考察了其体外经皮渗透性、月桂氮酮的促渗作用以及其体外释放。结果表明吡喹酮凝胶剂的体外经皮渗透为零级过程，皮肤为其经皮渗透的限速屏障，月桂氮酮能有效促进其体外经皮渗透，其体外释放符合Ｈｉｇｕｃｈｉ方程。
The solution phase diagram of praziquantel (1) was made using tricomponent solvent system, and the optimum percentage of each solvent in the 1% 1 hydrogel formulation was determined by uniform design:40% w/w of propylene glycol, 45% w/w of alcohol and 5% w/w of water. Hydrogel formulations were prepared by gelling the optimum solvent mixture with Carbopol 940. The percutaneous penetration of 1 hydrogel through excised mouse skin, the enhancement of laurocapram and release of it through cellophane were observed. It was found that percutaneous penetration of 1 hydrogel in vitro followed zeroorder kinetics, skin was the main barrier, laurocapram could effectively enhance the permeability, and release of 1 through cellophane was well described by the Higuchi's model.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1998年第4期161-164,共4页
Chinese Journal of Pharmaceuticals
