摘要
The revaluation of medicinal plants in the veterinary pharmacopoeia is essential for the development of livestock in Burkina Faso. In order to justify the use of C. sesamoides and S. hermonthica in the treatment of gastrointestinal parasitosis of small ruminants, a quantification of phenolic compounds as well as antioxidant activity and acute toxicité evaluation of both plants were performed. Acute toxicity was evaluated by administering a single dose of 2000 mg/kg body weight of aqueous extract of both plants to mice. The highest total polyphenol content for C. sesamo?des was obtained in the ethyl acetate fraction with 47.236 ± 2.57 mgEAG/100mg while that of S. hermonthica was 74.871 ± 2.57 mgEAG/100mg obtained with the n-butanol Fraction. The dichloromethane extract of S. hermonthica obtained the highest total flavonoid content with 7.31 ± 0.48 mgEQ/100 while the highest total flavonoid content of C. sesamo?des was obtained with ethyl acetate fraction with 5.4273 ± 0.35 mgEQ/100mg. The aqueous extract of C. sesamo?des obtained the highest content of condensed tannins with 3.028 ± 0.13 mgEAT/100mg. Both plant’s extracts did not show any signs of toxicity in NMRI mice after administration of the dose of 2000 mg/kg. The antioxidant activity by DPPH, FRAP and ABTS methods was good compared to those of Quercetin and Trolox taken as standard.
The revaluation of medicinal plants in the veterinary pharmacopoeia is essential for the development of livestock in Burkina Faso. In order to justify the use of C. sesamoides and S. hermonthica in the treatment of gastrointestinal parasitosis of small ruminants, a quantification of phenolic compounds as well as antioxidant activity and acute toxicité evaluation of both plants were performed. Acute toxicity was evaluated by administering a single dose of 2000 mg/kg body weight of aqueous extract of both plants to mice. The highest total polyphenol content for C. sesamo?des was obtained in the ethyl acetate fraction with 47.236 ± 2.57 mgEAG/100mg while that of S. hermonthica was 74.871 ± 2.57 mgEAG/100mg obtained with the n-butanol Fraction. The dichloromethane extract of S. hermonthica obtained the highest total flavonoid content with 7.31 ± 0.48 mgEQ/100 while the highest total flavonoid content of C. sesamo?des was obtained with ethyl acetate fraction with 5.4273 ± 0.35 mgEQ/100mg. The aqueous extract of C. sesamo?des obtained the highest content of condensed tannins with 3.028 ± 0.13 mgEAT/100mg. Both plant’s extracts did not show any signs of toxicity in NMRI mice after administration of the dose of 2000 mg/kg. The antioxidant activity by DPPH, FRAP and ABTS methods was good compared to those of Quercetin and Trolox taken as standard.
作者
Dicko Amadou
Kam Eric Sami
Hadidjatou Belem
Konaté Almamy
Tindano Basile
Meda Roland Nâg-Tiéro
Ahoua Angora Rémi Constant
Koné Mamidou Witabouna
Kaboré Adama
Traoré Amadou
Bayala Balé
Tamboura Hamidou Hamadou
Dicko Amadou;Kam Eric Sami;Hadidjatou Belem;Konaté Almamy;Tindano Basile;Meda Roland Nâg-Tiéro;Ahoua Angora Rémi Constant;Koné Mamidou Witabouna;Kaboré Adama;Traoré Amadou;Bayala Balé;Tamboura Hamidou Hamadou(Laboratoire de Biologie et Santé Animale (LaBioSA), Centre National de recherche Scientifique et Technologique (CNRST)/Institut de l’Environnement et de Recherches Agricoles (INERA), Ouagadougou, Burkina Faso;Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Unité de Formation et de Recherches en Sciences et Technique, Université Nazi BONI, Bobo Dioulasso, Burkina Faso;Laboratoire de Physiologie Animale (LaPA), Unité de Formation et de Recherches en Sciences de la vie et de la Terre, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso;Laboratoire de Botanique et Valorisation de la Diversité Végétale (LaBVDIV), Université Nangui Abrogoua, Abidjan, Côte d’Ivoire;Centre Suisse de Recherche en Côte d’Ivoire, Abidjan, Côte d’Ivoire)
