摘要
C. ambrosioides is a Congolese medicinal plant used in the treatment of several pathologies. This work was initiated to evaluate the analgesic and antipyretic effect of the aqueous extract of leaves of C. ambrosioides. Analgesic effect was evaluated by using the acetic acid-induced writhing, the Tilk Flick test as well as the pain induced by formaldehyde. The results obtained showed that the aqueous extract significantly reduces the number of abdominal writhes (p C. ambrosioides (400 and 600 mg/kg) compared to control group (saline water). This result suggests an antipyretic effect. Chemical screening revealed the presence of alkaloids, flavones and mucilage. The presence of alkaloids and flavones could explain the analgesic and antipyretic effects attributed to this aqueous extract.
C. ambrosioides is a Congolese medicinal plant used in the treatment of several pathologies. This work was initiated to evaluate the analgesic and antipyretic effect of the aqueous extract of leaves of C. ambrosioides. Analgesic effect was evaluated by using the acetic acid-induced writhing, the Tilk Flick test as well as the pain induced by formaldehyde. The results obtained showed that the aqueous extract significantly reduces the number of abdominal writhes (p C. ambrosioides (400 and 600 mg/kg) compared to control group (saline water). This result suggests an antipyretic effect. Chemical screening revealed the presence of alkaloids, flavones and mucilage. The presence of alkaloids and flavones could explain the analgesic and antipyretic effects attributed to this aqueous extract.
作者
Elion Itou Romaric De Garde
Etou Ossibi Arnaud Wilfrid
Tchiama Loui-Marie
Boukongo Roger Pavel
Mambeke Hono Roger
Morabandza Cyr Jonas
Abena Ange Antoine
Elion Itou Romaric De Garde;Etou Ossibi Arnaud Wilfrid;Tchiama Loui-Marie;Boukongo Roger Pavel;Mambeke Hono Roger;Morabandza Cyr Jonas;Abena Ange Antoine(Animal Physiology Laboratory, Faculty of Science and Technology, Marien University Ngouabi, Brazzaville, Congo;National Institute for Research in Health Sciences, Scientific City of Brazzaville (Formerly ORSTOM), Brazzaville, Congo;Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, University Marien Ngouabi, Brazzaville, Congo;Department of Natural Sciences, Ecole Normale Supérieure, Marien University Ngouabi Congo, Brazzaville, Congo)
