摘要
在以生命科学为研究重点的相关领域中,氟的受欢迎程度仅次于氮杂原子。因为氟是电负性最强的元素,在当今的医药、农业化学和材料科学中起着关键作用。而三氟甲氧基(OCF3)是一种关键的氟化结构,具有独特的物理化学特性。将OCF3基团引入有机分子中,对于设计和开发生物活性化合物具有重要价值。本篇综述主要讲关于合成三氟甲氧基化合物的一些令人印象深刻的策略。
In related fields with a focus on life sciences, fluorine is second only to nitrogen heteroatoms in popularity. Because fluorine is the most electronegative element, it plays a crucial role in today's medicine, agricultural chemistry, and materials science. And trifluoromethoxy (OCF3) is a key fluorinated structure with unique physical and chemical properties. Introducing OCF3 groups into organic molecules is of great value for the design and development of bioactive compounds. This review mainly discusses some impressive strategies for synthesizing trifluoromethoxy compounds.
出处
《有机化学研究》
2024年第1期60-73,共14页
Journal of Organic Chemistry Research
