摘要
近年来,以免疫检查点抑制剂(Immune Checkpoint Inhibitors, ICIs)为代表的免疫治疗,极大地提高了多种肿瘤的治疗效果,但总体反应率较低。因ICIs的有效性绝对依赖于能够识别和杀伤肿瘤细胞的T淋巴细胞浸润,故ICIs只对“热肿瘤”有效,而对“冷肿瘤”无效。本文通过梳理相关文献,系统、全面地探讨了阻碍T淋巴细胞激活与浸润的常见机制,并总结了重塑肿瘤免疫微环境(Tumor Immune Microenvironment, TIME)提高ICIs治疗效果的方法与研究进展。在免疫治疗时代,如何最大程度地挖掘ICIs的治疗潜力已成为研究热点,值得多角度探讨。In recent years, immune therapy represented by immune checkpoint inhibitors (ICIs) has greatly improved the treatment outcomes for various tumors, but the overall response rate remains low. The effectiveness of ICIs is entirely dependent on the infiltration of T lymphocytes that can recognize and kill tumor cells, which is why ICIs are only effective against “hot tumors” and ineffective against “cold tumors”. This article systematically and comprehensively discusses the common mechanisms that hinder T lymphocyte activation and infiltration by reviewing relevant literature, and summarizes methods and research progress in reshaping the tumor immune microenvironment (TIME) to enhance the efficacy of ICIs. In the era of immunotherapy, how to maximize the therapeutic potential of ICIs has become a research hotspot worthy of exploration from multiple perspectives.
出处
《临床医学进展》
2024年第9期858-868,共11页
Advances in Clinical Medicine
