摘要
可生物降解纳米粒子作为纳米级药物载体,在蛋白质、多肽、疫苗、基因等药物控制释放方面具有广阔的应用前景。它的优点不仅在于其能有效地降低药物毒性,屏蔽药物不良气味并对药物控制释放,纳米粒子超微小的粒径能够有效地穿越组织间隙被细胞吸收,可通过人体的毛细血管甚至血脑屏障(BBB)来发挥药效。本文重点介绍近年来国内外可生物降解纳米粒子制备方法的进展情况,同时概述了各种影响因素和条件,并对可生物降解纳米粒子的发展做出展望。
As a new drug delivery and controlled release device,biodegradable polymeric nanoparticles appear to be very promising and have been widely studied. Nanoparticles have more advantages over the microparticles,such as lowering toxicity,shielding odor and controlling release of drug effectively.Due to their subcellular size, nanoparticles can be absorbed by the cells through the tissue matrix and penetrate into the arterial wall without causing trauma,and even be able to cross the blood-brain barrier(BBB). This review emphasizes to introduce the manufacturing techniques of biodegradable nanoparticles and their influence factors.
出处
《化学工业与工程》
CAS
2004年第4期259-262,280,共5页
Chemical Industry and Engineering
基金
天津市科委重点攻关项目(项目编号:003112511)
关键词
纳米粒子
制备方法
控制释放
药物载体
nanoparticles
method of preparation
controlled release
drug delivery
