摘要
目的 探索高能聚焦超声热疗 (HIFU )治疗泌尿系统恶性肿瘤的疗效及其安全性。方法 2 0 0 2年 10月起 ,应用我院与上海交通大学联合研制的HIFU 2 0 0 1型高能聚焦超声治疗系统治疗泌尿系统晚期恶性肿瘤 13例 ,包括 5例晚期肾癌、4例浸润性膀胱癌、2例激素非依赖型前列腺癌、1例前列腺小细胞癌和 1例晚期前列腺肉瘤。对肿瘤靶组织进行HIFU治疗 ,并分别于治疗前、后行病变区B超、CT和 (或 )膀胱镜检查 ,随时记录症状变化、检查结果及并发症情况。结果 随访时间为 2～ 9个月。与治疗前相比 ,除 1例肾癌和 1例激素非依赖型前列腺癌的疗效不明显外 ,11例于治疗后 2周左右起B超示肿瘤组织内液化、坏死 ,回声明显增强 ,质地不均 ;CT示囊性改变 ,膀胱镜检查发现肿瘤乳头有坏死、脱落。 3例膀胱外浸润性包块萎缩 ,4例前列腺癌患者血清前列腺特异性抗原水平降低。治疗总有效率为 84 .6 % (11/ 13例 )。治疗过程中 ,所有患者的局部不适能耐受 ,无需特殊处理 ,治疗结束后无明显疼痛等不适。均无皮肤灼伤、穿孔、大出血等并发症。结论 HIFU可作为泌尿系统恶性肿瘤的一种新的治疗手段 ,尤其对晚期肿瘤患者 ,其近期疗效确切 ,且安全、方便。
Objective To explore the therapeutic efficacy of high intensity focused ultrasound (HIFU) in advanced malignant tumors of urinary tract. Methods From October 2002, thirteen urinary cancer patients were treated by HIFU, including 5 renal cell carcinoma, 4 bladder cancer, 2 non hormone dependent prostatic cancer, 1 small cell prostatic carcinoma, 1 prostatic sarcoma. HIFU technique was used to treat the target tumors. All cases were preoperatively examed and postoperatively followed up by symptom recording, ultrasound, CT scan, and/or cystoscopic examination. Complications and changes in symptoms were also recorded. Results All cause were followed up for 2～9 months. After HIFU treatment, tumors of 11 cases showed remarkable changes during the second week, such as liquefaction, necrosis,regression of bladder masses in 3 cases, and decrease of serum PSA level in 4 patients with prostatic cancer,the total rate of efficacy was 84.6%(11/13). No skin burn, pain, perforation or obvious hemorrhage occurred. Conclusion As a new treatment option, HIFU is effective and safe in the treatment of advanced malignant tumors of urinary tract.
出处
《上海医学》
CAS
CSCD
北大核心
2004年第5期292-294,共3页
Shanghai Medical Journal
