摘要
目的探讨无溶栓药物条件下超声+微泡对血栓溶解的作用。方法建立12只兔双侧股动脉急性血栓模型,对其中6只经静脉注射白蛋白微泡,一侧动脉接受经皮超声(超声+微泡组)而另一侧接受无超声治疗(微泡组)。另外6只兔一侧动脉只接受超声治疗(超声组)而另一侧不接受任何处理(对照组)。结果单独超声治疗的6条动脉只有2条再通,接受超声+微泡治疗的6条动脉全部实现再通(P=0.014),微泡组和对照组动脉无再通。超声+微泡组动脉再通时间和残余血栓面积比值显著小于超声组(P=0.004,P=0.003 )。结论超声作用下经静脉注射微泡能有效促进在体动脉血栓溶解,这对临床急性血栓形成患者有潜在的应用意义。
Objective To evaluate the efficacy of intravenous ultrasound microbubbles for thrombolysis of arterial thrombus without using thrombolytic drugs. Methods Twelve rabbit models of acute bilateral femoral artery thrombosis were established and 6 of them received transcutaneous ultrasound and intravenous albumin microbubble treatment for thrombosis on one side while only microbubble treatment for the other side. The other 6 rabbits received ultrasound treatment on one side but no treatment on the other to serve as the control group. Results None of the 6 arteries treated with microbubbles alone and only 2 arteries treated with ultrasound alone in the 6 control rabbits were recanalized. All the 6 femoral arteries treated with microbubbles together with ultrasound were recanalized (P=0.014), with significantly shorter patent time and smaller residual thrombus cross-sectional area than those of the arteries with only ultrasound treatment (P=0.004 and P=0.003, respectively). Conclusion Treatment with intravenous microbubbles assisted by transcutaneous ultrasound effectively promotes arterial thrombolysis in vivo, and this technique can be of significance in clinical treatment of acute thrombotic occlusions.
出处
《第一军医大学学报》
CSCD
北大核心
2004年第5期536-538,共3页
Journal of First Military Medical University
基金
国家自然科学基金(30270385)
广东省医学科研基金课题(A2003599)~~
