摘要
目的 探讨基质金属蛋白酶 - 9(MMP- 9)的表达与骨巨细胞瘤血管新生、肿瘤增殖、转移及复发的关系。方法 采用免疫组化法检测 82例骨巨细胞瘤标本 MMP- 9的表达 ,并分析其与肿瘤细胞增殖、血管形成及转移复发的关系。结果 骨巨细胞瘤中 MMP- 9的阳性表达率为 6 5 .85 %。MMP- 9表达强度与微血管密度(MVD)值显著相关 (P<0 .0 5 ) ,不同 MMP- 9表达组骨巨细胞瘤的复发率、转移率有显著差异 (P<0 .0 5 ) ,多因素 L ogistic回归分析显示 MMP- 9及手术方式对肿瘤复发有显著影响 (P<0 .0 5 )。结论 MMP- 9的表达与骨巨细胞瘤的血管生成、转移及复发有关 。
Objective To evaluate the expression of matrix metalloproteinase-9 (MMP-9) and its relationship to tumor angiogenesis,invasion and recurrence of giant cell tumors of bone.Methods The expressions of MMP-9 in 82 cases of human giant cell turmor (GCT) of bone were examined using immunohistochemical staining and intratumoral microvessel density was calculated.The expression of MMP-9,microvessel density (MVD) were analyzed with their relations to the invasion and recurrence of the tumor.Results The expression of MMP-9 in GCT of bone was 65.85%,and its expression was found a significant association with MVD(P<0.05).The rate of invasion and the rate of recurrence were significantly different between MMP-9 positive and negative group(P<0.05).Multiple logistic regression analysis revealed that operation methods and MMP-9 were related with recurrence(P<0.05).Conclusions The expression of MMP-9 is highly related to the invasion and recurrence of bone GCT,and can be used to predict the recurrence ability and guide the clinical therapy of bone GCT.
出处
《山东医药》
CAS
北大核心
2004年第15期9-10,共2页
Shandong Medical Journal
