摘要
目的:观察理气中药促胃肠动力作用及作用机制. 方法:观察10种理气中药对健康小鼠服药前后胃内残留率及小肠推进率的变化;以大鼠腹腔注射L-Arg造成的大鼠胃肠运动障碍模型为对象,探讨木香及大腹皮对模型大鼠胃肠运动及胃动素、NO的影响. 结果:理气中药中大腹皮、陈皮、砂仁、厚朴、木香对健康小鼠胃残留率明显低于对照组;陈皮、大腹皮、枳实、砂仁、苦楝子、香附对正常小鼠小肠推进率明显高于对照组(P<0.05);大腹皮、木香对造模大鼠用药后胃动素较造模组显著升高(P<0.05);大腹皮使造模大鼠血中一氧化氮显著下降(P<0.05).木香、大腹皮能显著改善造模大鼠的胃排空(P<0.05),且与西沙必利间无明显差异(P>0.05). 结论:理气中药木香、大腹皮、砂仁、厚朴、陈皮有明显的促进胃排空作用;木香、大腹皮作用明显强于砂仁、厚朴、陈皮;木香的作用优于西沙必利.枳实、大腹皮、陈皮、香附、砂仁、苦楝子有促进小肠传输功能.木香、大腹皮能明显改善L-Arg所致胃排空障碍.木香、大腹皮对L-Arg所致小肠传输功能障碍无改善作用.
AIM: To study the effects of Chinese qi-regulating medicine on gastrointestinal motility and their mechanism. METHODS: The effect of the qi-regulating medicine on gastrointestinal motility was investigated by measuring the rate of the semisolid paste remaining in stomach and the rate of the semisolid paste's propulsion in the small intestine. To study the difference of gastrointestinal motility, motilin and NO produced by the radix aucklandiae and pericarpium arecae, a rat model of the abnormal gastrointestinal motility was induced by injecting L-Arg into rat's abdominal cavity. RESULTS: Pericarpium arecae, Radix aucklandiae, Fructus amomum villosum, Cotex magnolia officinal and Pericar piumcitri petcultae had effects on gastric emptying in the rats (P<0.05). Fructus aurantii immaturus, Pericarpium arecae, Pericar piumcitri petcultae, Rhizoma cyperi, Amomum villosum and Melia toosenda had effects on small intestinal propulsion in the rats (P<0.05). Pericarpium arecae and Radix aucklandiae inhibited the effects of L-Arg on increasing the serum NO and on decreasing the plasma motilin (MTL) in rats (P<0.05). Pericarpium arecae and Radix aucklandiae could improve gastric emptying in the rat model. CONCLUSION: Pericarpium arecae, Radix aucklandiae, Fructus amomum villosum, Cotex magnolia officinal and Pericar piumcitri petcultae can pomote the gastrointestinal motility and the effects of Pericarpium arecae and Radix aucklandiae are stronger than others. Fructus aurantii immaturus, Pericarpium arecae, Pericar piumcitri petcultae, Rhizoma cyperi, Amomum villosum and Melia toosenda can promote the small intestine's transmission function. Pericarpium arecae and Radix aucklandiae are able to improve the abnormal gastric dynamics in the rats, but can not improve the obstacle of small intestine transmission function made by L-Arg.
出处
《世界华人消化杂志》
CAS
2004年第5期1136-1138,共3页
World Chinese Journal of Digestology
