摘要
目的 :评价国产奥沙利铂 (oxaliplatin ,L OHP)联合氟尿嘧啶及甲酰四氢叶酸 (CF)治疗大肠癌的疗效和毒副反应。方法 :2 8例晚期大肠癌患者 ,予国产L OHP 12 0mg/m2 ,静脉滴入 ,持续 2h ;CF 15 0mg/m2 ,静脉滴入 ,持续 2h ;5 -氟尿嘧啶 ( 5 FU ) 5 0 0mg/m2 ,静脉滴入 ,持续 >4h ,于CF滴完后用。每 3周重复 1次 ,用药 2个周期后评价疗效。结果 :2 8例患者中 ,无完全缓解 (CR) ,部分缓解 (PR) 9例 ,稳定 (SD) 12例 ,进展 (PD) 7例 ,总有效率(RR ,CR +PR) 3 2 1% ( 9/2 8) ,中位无进展生存期 6 7个月 ,中位生存期 9 8个月。毒副反应主要是末梢神经毒性、恶心呕吐、骨髓抑制及静脉炎等 ,患者均可耐受。结论 :国产L OHP联合 5 FU
OBJECTIVE:To evaluate the therapeutic effect and toxicity of oxaliplatin (L-OHP) plus 5-FU/CF in advanced colorectal cancer.METHODS:Twenty-eight patients with advanced colorectal cancer received L-OHP plus 5-FU/CF.L-OHP 120 mg/m 2 was administered,iv infusion for two hours,leucovorin (CF)150 mg/m 2,iv infusion for 2 hours,followed by 5-FU 500 mg/m 2 iv infusion over a period of 4 hours.This regimen was repeated every 3 weeks.RESULTS:Among 28 patients,there were CR 0,PR 9,SD 12,PD 7.An overall response rate (CR+PR) was 32.1%,median time to progress (TTP) 6.7 months and median survival 9.8 months.The major toxicity and side effects were nausea and vomiting,neurosensory toxicity,neutropenia and peripheral phlebitis,but they were acceptable.CONCLUSION:The combinatian of oxaliplatin and 5-FU/CF is an effective and tolerable regimen for treatment of advanced colorectal cancer.
出处
《肿瘤防治杂志》
2004年第3期303-304,310,共3页
China Journal of Cancer Prevention and Treatment
