摘要
目的研究亚低温 (mildhypothermia)对缺氧缺血新生猪血液粘滞度和凝血功能的影响。方法生后7日龄上海种白猪25只 ,制备缺氧缺血模型 ,随机分成A组 (低温36℃72h组 ,n=8)、B组 (低温34℃24h组 ,n=8)和C组 (常温对照组 ,n=9) ,分别于缺氧缺血 (HI)前、HI后2h、24h和72h测定血液粘滞度、血D_二聚体水平和血小板计数。结果HI前、HI后2h、24h和72h各时间点各组高、中、低切变率的血液粘滞度比较差异无显著性 ,各时间点各组D_二聚体水平比较差异无显著性 ,同时血小板计数比较差异亦无显著性。结论体温下降3℃～5℃的亚低温治疗并未加重缺氧缺血新生猪血液粘滞度和凝血功能异常。
Objective To explore the effect of mild hypothermia on blood coagulation and viscosity in neonatal piglets with hypoxic ischemic(HI)brain injury.Methods Twenty five7_days_old piglets were subˉjected to hypoxic ischemic brain damage(NIBD)by the method of temporary occlusion of the bilateral carotid arteries,followed by mechanical ventilation with low oxygen concentration(FiO 2 =0.06)for30minutes.The piglets were then randomized to the following groups:group A(body temperature36℃for72h,n=8);group B(body temperature34℃for24h,n=8)and group C(normothermia,body temperature38℃for72h,n=9). The blood viscosity,D_dimmer and blood platelet counts were measured at pre_HI,2h,24h,and72h after HI,respectively.Results No significant differences were observed in blood viscosity,D_dimmer and blood platelet counts at above four time interval among three groups.Conclusions No significant complications of blood coagulation and viscosity during mild hypothermia were found in the study.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2004年第1期46-48,共3页
Journal of Clinical Pediatrics
基金
"九五"国家重点科技计划资助 (编号 :96 -904 -06 -04)
