摘要
【目的】探讨原发性结外淋巴瘤 (PENL)的免疫表型特点及其预后意义。【方法】用免疫组化S P法检测 5 4例PENLCD3 、CD45RO、CD2 0 和CD79a的表达情况。随访观察免疫表型特点及其与预后的关系。【结果】CD3 、CD45RO、CD2 0 和CD79a在T细胞型PENL的表达率分别为 10 0 %、76 .7%、3.3%和 8.3% ,在B细胞型PENL的表达率分别为 0 %、5 .2 %、95 .8%和 92 .9%。生存 2年以上的 8例PENL患者均为B细胞型PENL。【结论】CD3 诊断T细胞型PENL具有高度敏感性和高度特异性 ;CD2 0 、CD79a诊断B细胞型PENL敏感性高但特异性不足 ;B细胞型PENL的预后较好。
Objectives]To explore the immunophenotypic characteristics of primary extranodal lymphoma (PENL) and its prognostic significance.The expressions of CD 3?CD 45RO ?CD 20 and CD 79a in fifty-four cases of PENL were detected by immunohistochemical S-P method, their immunophenotypic characteristics and its relation to prognosis were followed up.The expressions of CD 3?CD 45RO ?CD 20 and CD 79a in T cell Type PENL were 100%,76.7%,3.3% and 8.3% ,respectively; while those in B cell type PENL were 0%, 5.2%,95.8% and 92.9%, respectively. All of eight PENL patients survived for more than two years belonged to B cell type PENL.[Conclusion]Diagnosis of T cell type PENL by CD 3 detection shows high sensitivity and high specificity ; whereas detection of CD 20 and CD 79a displays high sensitivity but less specificity for the diagnosis of B cell type PENL. The prognosis of B cell type PENL is somewhat better.
出处
《医学临床研究》
CAS
2004年第2期145-147,共3页
Journal of Clinical Research
