摘要
目的 探讨 1996～ 2 0 0 0年我国围产儿腭裂畸形的流行病学特征。方法 中国出生缺陷监测网是一个以医院为基础的先天畸形监测系统 ,采用此监测网收集孕 2 8周到产后 7d住院分娩的围产儿相关资料进行评价。结果 共收集围产儿 2 2 186 16例 ,腭裂缺陷儿 4 99例 ,总发生率为 2 2 5 万。单发腭裂发生率为 1 75 万 ,综合征性腭裂为 0 5 0 万 ;城镇 2 2 7 万 ,乡村 2 19 万 ;男性为 1 93 万 ,女性为 2 5 7 万。产妇年龄别发生率以≥ 35年龄组最高(2 84 万 ) ,但各年龄组间无显著差异。总的腭裂和综合征性腭裂年度发生率呈上升趋势。各省发生率差异明显。单发和综合征性腭裂围产期病死率分别为 7 3% ,4 1 4 % ,总病死率为 14 9%。结论 中国围产儿腭裂畸形发生率的上升趋势由综合征性腭裂所致。单发腭裂畸形女性发生率高于男性。腭裂发生率存在明显地理差异。综合征性腭裂围产儿出生素质差 。
Objective To study the epidemiological features of cleft palate (CP) in Chinese perinatals.Methods Data from 1996 to 2000 were collected through Chinese Birth Defects Monitoring Network a hospital based congenital malformation registry system. During that period all live or still births with 28 weeks of gestation or more were assessed within 7 days after delivery.Results 499 perinatals with CP were identified among 2 218 616 births, then the overall prevalence rates of CP were 2 25/10 000, rates in isolated and syndromic CP were 1 75/10 000, 0 50/10 000 respectively. The rates in urban and rural area, in male and female births were 2 27/10 000 and 2 19/10 000, 1 93/10 000 and 2 57/10 000 respectively. The highest but nonsignificant rate (2 84/10 000) was found in maternal age group of more than 35 years. An increased trend was found both in overall CP and syndromic CP during that period. Geographic variation was found among provinces. The perinatal mortality rate of CP was 14 9%, and the rate of isolated forms was 7 3%, while the rate of syndromic CP was as high as 41 4%.Conclusion The increasing prevalence rate of syndromic CP can account for the secular trend of overall CP. Female predominance was only observed in isolated forms of CP among Chinese perinatals. Geographic variation was identified too. Due to poor birth quality, perinatals suffering from syndromic CP had poor prognosis.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2004年第1期35-37,共3页
West China Journal of Stomatology
