摘要
目的探讨喜炎平注射液、氨溴特罗口服溶液联用于支气管肺炎患儿的效果。方法选取2017年9月至2019年1月沈阳医学院附属中心医院儿科收治的76例支气管肺炎患儿作为研究对象,按双盲法分组标准分为对照组和研究组,对照组(n=38)给予氨溴特罗口服溶液治疗,研究组(n=38)在对照组治疗基础上加用喜炎平注射液治疗。比较两组患儿治疗效果、治疗前后炎症介质水平、临床症状消失时间、不良反应发生率以及住院时间。结果研究组治疗有效率为97.37%,明显高于对照组的84.21%,治疗后炎症介质水平均优于对照组,临床症状消失时间及住院时间短于对照组,差异均有统计学意义(均P<0.05);两组治疗后不良反应发生率比较差异无统计学意义(P>0.05)。结论小儿支气管肺炎采用氨溴特罗口服溶液联合喜炎平注射液治疗能提高疗效,减轻炎症反应,促进康复,安全有效。
Objective To explore the efficacy of Xiyanping Injection(喜炎平注射液)combined with ambroxol and clenbuterol oral solution in children with bronchopneumonia.Methods A total of 76 children with bronchopneumonia admitted to the Pediatric Department of the Central Hospital Affiliated to Shenyang Medical College from September 2017 to January 2019 were selected as the research subjects.They were divided into control group and study group according to the double-blind method.The control group(n=38)was treated with ambroxol and clenbuterol oral solution,and the study group(n=38)was treated with Xiyanping Injection(喜炎平注射液)on the treatment basis of the control group.Therapeutic effect,levels of inflammatory mediators before and after the treatment,disappearance time of clinical symptoms,incidence of adverse reactions and hospitalization time were compared between the 2 groups.Results The effective rate of treatment in the study group was 97.37%,which was significantly higher than 84.21%in the control group.After the treatment,the levels of inflammatory mediators were better than those in the control group.The disappearance time of clinical symptoms and hospitalization time were shorter than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Ambroxol and clenbuterol oral solution and Xiyanping Injection(喜炎平注射液)for pediatric bronchopneumonia can improve the efficacy,reduce the inflammatory reaction,and promote rehabilitation,with safety and effectiveness.
作者
刘畅
麻洁心
岳晓红
隋登宇
LIU Chang;MA Jie-Xin;YUE Xiao-Hong;SUI Deng-Yu(Department of Pediatrics,Affiliated Central Hospital of Shenyang Medical College,Shenyang 110024,China)
出处
《中国药物经济学》
2019年第7期58-61,共4页
China Journal of Pharmaceutical Economics
关键词
支气管肺炎
喜炎平注射液
氨溴特罗口服溶液
儿童
炎症反应
Bronchopneumonia
Xiyanping Injection(喜炎平注射液)
Ambroxol and clenbuterol oral solution
Children
Inflammatory reaction
